A new method to monitor early sign of oxidative stress that triggers cancer spread has been developed by scientists from University of Michigan. Lead researcher Kate Carroll suggests that being able to monitor a marker of oxidative stress that is associated with the activation of tumor cell growth pathways, particularly at an early stage, and then tailor treatments accordingly would allow for more targeted studies and might improve the odds of success with antioxidants and pro-oxidants. The new method detects sulfenic acid in proteins-a tip off to early oxidative stress and to a specific protein modification associated with cell growth pathways. Sulfenic acid is produced when a particular oxidant, hydrogen peroxide, reacts with the protein building block cysteine. But because the chemical modification involved is so small and transient, it has been difficult to detect. To get around that problem, Carroll and Seo used a chemical probe that "traps" sulfenic acid and tags it for recognition by an antibody. The antibody is labeled with a fluorescent dye that glows when observed with a fluorescence microscope. The researchers then used the method to assess sulfenic acid levels as a marker of oxidative stress in several systems, including a panel of breast cancer cell lines. "For each line, we saw a very distinct pattern of sulfenic acid modifications," indicating different oxidative stress levels and hinting at differences in the underlying molecular events associated with tumor growth," said Carroll, assistant professor of chemistry and a research assistant professor in the Life Sciences Institute. "Whether the patterns we see will correlate with response to antioxidant treatment or other therapies that modulate oxidative stress level remains to be seen, but now we at least have a way to investigate that question," the expert added. The study appears in Proceedings of the National Academy of Sciences.Source: ANIRAS << Neuropathic Pain After Spinal Cord Injury may be Relieved b... Two Leading Causes of Pneumonia Revealed >> Recommended Reading Breast Cancer during Pregnancy Management of breast cancer during pregnancy or pregnancy associated breast cancer requires special consideration to avoid harm to the fetus. READ MORE Cervical Cancer - Incidence Cervical cancer is the second most common cancer among women and is the primary cause of cancer-related deaths in developing countries READ MORE Andropause / Male Menopause Andropause or male menopause causing low libido in a man is due to decreasing level of male hormones, like testosterone. Symptoms of andropause are depression, irritability. READ MORE Heart Attack- Lifestyle risks Heart attack is the death of the heart muscle due to loss of blood supply. Simple guidelines to avoid heart attack are listed. READ MORE Is Your Man Moody? Women get confused by the behavior of men in their lives. It is time they realize that men too have frequent mood swings. READ MORE Palpitations And Arrhythmias Palpitations are unpleasant sensation of one’s own heartbeat. READ MORE Stress and the Gender Divide Stress has become entwined in the current lifestyle of a young working couple and has resulted in the rise in incidence of hypertension, diabetes and psychosomatic illnesses. READ MORE Tattoos A Body Art Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look READ MORE Most Popular on Medindia Nutam (400mg) (Piracetam) A-Z Drug Brands in India Vent Forte (Theophylline) More News on: Cancer and HomeopathyPalpitations And ArrhythmiasStress Relief Through Alternative MedicineStress and the Gender DivideCancer FactsAndropause / Male MenopauseCancerTattoos A Body ArtHeart Attack- Lifestyle RisksIs Your Man Moody?