A new blood test developed by researchers at Mount Sinai Hospital in the US shows promise for early diagnosis of the disease, although there are currently no fully validated blood signatures or biomarkers for Parkinson's disease (PD).
Parkinson's disease is a chronic and progressive movement disorder and mutations in a gene are known to increase the likelihood of developing Parkinson's Disease (PD).
Comparing the tests conducted in mice and humans, the researchers identified ribonucleic acids or RNA signatures that can be measured in blood samples that correlate with mutations in the gene LRRK2.
The researchers analyzed the blood of four groups of mice with genetic material (e.g. ribonucleic acids or RNA) predicted by researchers to form part of a PD signature. Researchers also examined the blood of a group of Ashkenazi Jewish patients living with PD, as well as a separate group of healthy controls.
The study was published in Movement Disorders.