About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Scientists Develop Gene Screen Method to Identify Causes of Autism

by Rajashri on October 17, 2008 at 2:58 PM
Font : A-A+

 Scientists Develop Gene Screen Method to Identify Causes of Autism

Scientists have developed a new screening method, called 'multiplex ligation-dependent probe amplification' (MLPA) to detect genetic defects linked with autism spectrum disorders (ASDs).

The new technique will help clinicians identify the underlying causes of some patients' ASDs.

Advertisement

Led by Joseph Buxbaum from Mount Sinai School of Medicine, New York, researchers evaluated the use of MLPA.

MLPA is a recently developed method of investigating DNA, in genetic counselling.

"MLPA is a relatively practical, inexpensive and fast tool for screening chromosome rearrangements in autism spectrum disorders," said Buxbaum.
Advertisement

ASDs have been linked with genetic abnormalities and have also been found to cause some degree of cognitive impairment in children.

For the study, MLPA was used on a group of 279 children with ASD, to find out the abnormalities known to be associated with cognitive impairment.

"By focussing on well-known genetic disorders, rather than assaying an individual's entire genome, MLPA allows for much more efficiency," said Buxbaum,

With the identification of more genetic abnormalities associated with ASDs, doors are opened for using more probes in future screens.

Also, while demonstrating the effectiveness of MLPA as a screen for known genetic disorders, the authors also identified some new genetic changes that are likely to contribute to ASD.

The genetic changes include novel duplications (extra copies of genetic material) in chromosomes 15 and 22, which may increase liability and/or exacerbate ASD symptoms.

While there is no known cure for ASDs, early detection and commencement of special education and behavioural therapy can allay some of the negative symptoms.

The study is described in the open access journal BMC Medical Genomics.

Source: ANI
RAS/SK
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
January is the Thyroid Awareness Month in 2022
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
DNA Finger Printing Autism 

Recommended Reading
Autism
Autism is a neurodevelopmental disorder typically characterized by impaired social and ......
Autistic More Rational in Their Decisions
A new study has found that people with autism-related disorders are less likely to make irrational ....
Why Autistic Kids Face Difficulty in Learning New Things?
Scientists have found the answer to why children with autism spectrum disorders have trouble in ......
Study Uncovers Chromosomal Abnormality Behind Broad Range of Disorders in Kids
A collaborative study has revealed a submicroscopic aberration in a particular region of ......
DNA Finger Printing
DNA fingerprinting is a technique which helps forensic scientists and legal experts solve crimes, id...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)