Scientists have created the three-dimensional (3-D) structures of intact mammalian genomes from individual cells, leading to a potential advance of stem cells in medicine.
The 3-D structure shows how the DNA from all the chromosomes intricately folds to fit together inside the cell nuclei.
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‘Visualising a genome in 3D at such an unprecedented level of detail is an exciting step forward in research.’
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The new approach, detailed in the journal Nature, also enables researchers to determine the structures of active chromosomes inside the cell and how they interact with each other to form an intact genome.
"Visualising a genome in 3D at such an unprecedented level of detail is an exciting step forward in research and one that has been many years in the making. This detail will reveal some of the underlying principles that govern the organisation of our genomes - for example how chromosomes interact or how structure can influence whether genes are switched on or off," said Tom Collins from Wellcome trust -- a London-based non-profit.
![Synthetic DNA Motor can Help in Early Detection of Cancer]( "Synthetic DNA Motor can Help in Early Detection of Cancer")
Synthetic DNA motors can work in living cells and help early detection of deadly diseases such as cancer and also make drug delivery more precise.
The genome's structure controls when and how strongly genes -- particular regions of the DNA -- are switched 'on' or 'off,' while playing a critical role in the development of organisms and also, when it goes awry, in disease.
The study may help study how this changes as stem cells differentiate and how decisions are made in individual developing stem cells, which may be key to realising the potential of stem cells in medicine.
"If we can apply this method to cells with abnormal genomes, such as cancer cells, we may be able to better understand what exactly goes wrong to cause disease, and how we could develop solutions to correct this," Collins said.
Source: IANS
Synthetic DNA Motor can Help in Early Detection of Cancer
Synthetic DNA motors can work in living cells and help early detection of deadly diseases such as cancer and also make drug delivery more precise.
Advertisement
The genome's structure controls when and how strongly genes -- particular regions of the DNA -- are switched 'on' or 'off,' while playing a critical role in the development of organisms and also, when it goes awry, in disease.
The study may help study how this changes as stem cells differentiate and how decisions are made in individual developing stem cells, which may be key to realising the potential of stem cells in medicine.
"If we can apply this method to cells with abnormal genomes, such as cancer cells, we may be able to better understand what exactly goes wrong to cause disease, and how we could develop solutions to correct this," Collins said.
Source: IANS
Start Codons in DNA may be More Numerous
DNA is transcribed into messenger RNA (mRNA), and mRNA is translated into proteins, which are essential for almost all biological functions.
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 Novel DNA Computer may Boost Controlled Drug DeliveryA novel DNA computer is capable of detecting several antibodies in the blood, that may allow better control of the medication for diseases. | Advertisement
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