About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Row, Row, Row a Boat Gently on the Genes?

by Hannah Punitha on September 27, 2007 at 8:23 PM
Font : A-A+

Row, Row, Row a Boat Gently on the Genes?

A safer and more efficient alternative method is used for ferrying genes of interest into cells using the new non-viral gene delivery systems using transposons

These jumping genes may provide safer and a more efficient gene delivery system.

Advertisement

Margy Lambert, a molecular biologist and biological safety expert, has described the gene delivery potential of transposons, also known as "jumping genes", in an article published in the journal Applied Biosafey.

The researcher says that scientists and gene therapists have to date used two proven options to move a gene from one point to another, according to the background information in the article. One of these methods involves a virus, while the other a plasmid, an engineered loop of DNA that usually delivers the genes on a short-term basis, the article adds.
Advertisement

Viruses can be infectious and some types of viruses occasionally land in a target genome near an oncogene and raise the risk of cancer. Plasmids, on the other hand, do not carry that risk, but they are not nearly as efficient at reproducing in cells, which is important for integrating an introduced gene into the targeted cells of the organism or patient.

Lambert says that "jumping genes" can provide a safer alternative than viruses and more efficient delivery than plasmids.

"Almost any application where you use viral vectors, you could use this technique. You can do a lot with it, and it is safer. Problems with viral vectors are extremely rare, but the consequences can be severe," says Lambert.

The researcher says that jumping gene technology has been found to be more effective than simple plasmids at achieving stable expression of genes introduced into animal cells.

Lambert revealed that in order to harness jumping genes, researchers use an enzyme to ferry a desired DNA sequence from one DNA molecule to another inside a cell. The enzyme can then be turned off to stop genes from jumping, says the expert.

Although Lambert admits that there are both technical and safety issues to be worked out in the development of transposon vectors before they could be tried in human therapy, the researcher insists that the use of such new vectors "offers a great opportunity to maximize the advantages and minimize the drawbacks of existing delivery systems."

Source: ANI
SPH /J
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
January is the Thyroid Awareness Month in 2022
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.


Recommended Reading
New Genes Can Come Out Of Nowhere Too
American researchers say that the discovery of a new fruit fly gene suggests that new genes need .....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)