About Careers MedBlog Contact us

Roughly Half of the Human Genome Made Up of Jumping Genes

by Kathy Jones on June 27, 2010 at 1:49 PM
Font : A-A+

 Roughly Half of the Human Genome Made Up of Jumping Genes

Transposons or 'jumping genes', which create genomic instability and are implicated in cancer and other diseases, make up roughly half of the human genome, geneticists have revealed.

"Now it looks like every person might have a new insertion somewhere," says senior author Scott Devine, associate professor of medicine at the University of Maryland School of Medicine's Institute for Genome Sciences.


Transposons are like small self-replicating sequences that transfer themselves from one generation to another. But the scientists faced the overwhelming problem of finding a new insertion within three billion base pairs.

Their study indicated transposons are jumping in tumours and are generating a new kind of genomic instability. They are already known to interrupt genes and cause human diseases, including neurofibromatosis, hemophilia and breast cancer.

Scientists believe a process called methylation, which silences genes during differentiation also shuts off transposons' ability to jump. Analysing the patterns of mutations in the lung tumours suggested that during tumour formation, modified methylation patterns may be allowing transposons to re-awaken, Devine says.

The results are published in the June 25, 2010 issue of Cell.

Source: ANI
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Roughly Half of the Human Genome Made Up of Jumping Genes Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests