Rotavirus Vaccination Linked to Reduced Infant Diarrhea Deaths

by Colleen Fleiss on  August 13, 2018 at 12:45 AM Drug News
RSS Email Print This Page Comment bookmark
Font : A-A+

In rural Malawi, a region with high levels of child deaths, rotavirus vaccination was found to reduce infant diarrhea deaths by 34%, shows study.
Rotavirus Vaccination Linked to Reduced Infant Diarrhea Deaths
Rotavirus Vaccination Linked to Reduced Infant Diarrhea Deaths

The study led by scientists at the University of Liverpool, UCL, Johns Hopkins Bloomberg School of Public Health and partners in Malawi provides the first population-level evidence from a low-income country that rotavirus vaccination saves lives.

The findings, published in The Lancet Global Health, add considerable weight to the World Health Organisation's (WHO) recommendation for rotavirus vaccine to be included in all national immunisation programmes.

Rotavirus is the most common cause of diarrhea disease among infants and young children. Despite improvements in sanitation and case management, rotavirus still caused 215,000 child deaths in 2013, with 121,000 of these in Africa. With support from Gavi, the Vaccine Alliance, many countries in Africa with high death rates have added rotavirus vaccine to their routine immunisation programme over the past five years.

To determine the vaccine's impact on infant diarrhea deaths, researchers carried out a large population-based birth cohort study of 48,672 infants in Malawi, which introduced a monovalent rotavirus vaccine in October 2012.

As low-income African countries often lack birth and death registries - a resource used for similar impact studies in middle-income countries - the investigators and their study team of more than 1,100 people visited the homes of infants in 1,832 villages over the course of four years to collect data, including the infants' vaccination status and whether they survived to age one.

The study findings reveal that children who received the rotavirus vaccine had a 34% lower risk of dying from diarrhoea, which is a similar impact to that observed in middle-income countries.

"This is encouraging because children from the sub-Saharan African region account for more than half of global diarrhoea deaths, and with over 30 African countries thus far introducing rotavirus vaccine, the absolute impact on mortality is likely to be substantial," said one of the report's lead authors Dr Carina King, a senior research associate at UCL's Institute for Global Health.

Co-lead author Dr Naor Bar-Zeev, Associate Professor of International Health at the International Vaccine Access Center of the Johns Hopkins Bloomberg School of Public Health, added: "We already knew that rotavirus vaccine reduces hospital admissions and is highly cost-effective in low-income countries with a high burden of diarrhoeal disease, and now we've been able to demonstrate that it saves lives.

"However not all countries are vaccinating against rotavirus yet, including some very populous countries. The key message of this paper is that to do the best by all our children and to help them survive, all countries should introduce rotavirus vaccination."

The researchers also found a direct link between the proportion of the population vaccinated and the reduction in mortality that achieved. Malawi had a strong immunisation programme and was very proactive in planning to introduce rotavirus vaccine, which made it possible to scale up coverage rapidly.

"Within about a year from vaccine introduction, we were able to reach up to 90% of the population. It is vitally important that rotavirus vaccines reach all children, especially the most vulnerable living in poorer settings where the impact of vaccination is greatest," said one of the authors Dr Charles Mwansambo, Chief of Health Services for Malawi.

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions
Advertisement

Recommended Reading

More News on:

Cholera Amoebic Dysentery Colo-rectal cancer - Management Crohns Disease Diarrhea Symptom Evaluation Norovirus Travelerīs Diarrhea Top 10 Vaccine Myths Debunked Traveling with Children Abroad? - Parents, Stay Alert! Dehydration in Children / Pediatric Dehydration 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive