Johns Hopkins scientists have found that sugar plays a significant role in how cells work, paving the way for new therapies for a number of diseases like diabetes, neurodegeneration, and cancer.
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The researchers say that sugar may be as influential as phosphate in putting the proteins in cells on and off.
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The latest research paper by the Johns Hopkins team suggests that sugar also plays a role in regulating phosphorylation itself.
The team say that the new switches form yet another potential target for manipulation by drugs.
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The researcher revealed that it was with the aid of new technologies that they could measure the extent to which the addition of sugar to proteins affects phosphorylation.
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"The influence of sugar is striking. The presence of O-GlcNAc causes the enzymes that add the phosphate to do something different, and this cross-talk itself can modify proteins," Hart says.
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"With regard to cancer, diabetes and Alzheimer's, most people in the world today have been studying the yang (phosphorylation) but not the yin (GlcNAcylation). There's another whole side that people were unaware of where diabetes diagnostics and cancer therapies could be targeted," says Hart.
Source-ANI
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