Roche will make an initial payment to the two companies, a statement said without divulging the exact sum. But it added that the final payout could reach $750 million (636 million euros).
Approximately 65 percent of global antibiotic sales are of the beta-lactam class of antibiotics which includes penicillins, cephalosporins, monobactams and carbapenems. However, the efficacy of these life-saving antibiotics is threatened by rising bacterial resistance caused by beta-lactamase enzymes which render the antibiotics increasingly ineffective. The Centers for Disease Control (CDC) estimates that more than two million patients are affected by drug-resistant infections each year in the United States, with direct healthcare costs as high as $20 billion.
Christopher G. Micetich, founder and CEO of Fedora Pharmaceuticals said, "The properties of OP0595 and its ability to be combined with new or existing beta-lactam antibiotics promise a significant advance in the battle against increasing multi-drug-resistant bacteria."