Medindia
Advertisement

Risky Method of Anti-cancer Therapy

by Colleen Fleiss on December 28, 2018 at 8:37 AM
Font : A-A+

Risky Method of Anti-cancer Therapy

Scientists of Far Eastern Federal University (FEFU) have suggested a risky method of anti-cancer therapy. Their review of mechanisms for molecular activation of stem cells of gliomas (most widely-spread brain tumors) was approved for publishing in the Frontiers in Cellular Neuroscience journal.

The scientists focused on the transition of cancerous stem cells from sleeping to awake mode and further to active division. Stem cells are rare cells that are responsible not only for a tumor's growth and spreading, but also for its relapsing which poses a major problem for modern therapy. A tumor may relapse soon after a surgery or chemotherapy, or it may take long time to return.

Advertisement


The difficulty of the therapy lies in the fact that stem cells may be influenced only in their active phase which is difficult to detect.

"The method of stem cells activation is quite risky. However, in their passive state these cells are almost immune to chemotherapy. In cases of late stage tumors one always has to choose between potential risks and benefits of a certain treatment method. We consider the method of "rebooting" cancer cells to be one of the most promising," says Alexander Kagansky, head of the Center of Genome and Regenerative Medicine at FEFU, and a specialist in epigenetics who led the research group.
Advertisement

While certain specific cell channels are blocked in the course of the therapy, the blockage is compensated by a number of molecular links working on a different level.

This issue may be resolved with the help of differential therapy. The idea is to make the stem cells of a glioma reboot the cell cycle, i.e. to bring them into their active state and to attack them unexpectedly with chemotherapy at the moment when they're already not sleeping, but are not yet protected.

"We would like to focus on an extremely important question: whether the peculiarities and molecular mechanisms of the cells surrounding glioma stem cells affect the activation of the latter, or they are activated independently," says Alexander Kagansky.

Cancer stem cells may remain sleeping for a long time and be activated unexpectedly under the influence of an external factor, such as physical trauma or psychological stress.

Modern studies do not pay enough attention to the mechanisms of cancer stem cells activation because they are difficult to identify. They are also genetically similar to regular stem cells, although the cells of gliomas have their specific features, namely genetic peculiarities. Scientists also know that the spreading of the tumors are determined by mutations in specific proteins. However, it is still unclear how these proteins are connected to the activation of tumor stem cells.

Another cancer treatment method covered by the article (and also illustrated with glioma as an example) is associated with molecular profiling of tumor cells. The idea is that scientists should identify genetic peculiarities of tumor cells and find out its dominant gene and specific markers. To obtain such information on all required subcellular levels means to enter a new stage in the development of oncology and medicine in general.

However, for this method to be successfully developed, further studies of cancer stem cells hierarchy and the mechanisms that activate or deactivate them are required.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Gonorrhea
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Reiki and Pranic Healing Top 10 Health Benefits of Cloves 

Recommended Reading
Brain Tumor
Brain tumors are the abnormal growth of brain cells that may be benign or metastatic. Brain tumors ....
Brain Tumor in Children
An abnormal growth of cells in the brain is called brain tumor. Most tumors arise within the brain ...
Quiz on Brain Tumor
Brain tumor is a group of cells with abnormal growth in the brain. A primary brain tumor indicates ....
Lifetime Risk Calculator for Cancers
What are your chances for developing some common cancers in your lifetime - find out now....
Top 10 Health Benefits of Cloves
Clove doesn’t just enhance the flavor of food, but, keeps your health in check by keeping diabetes, ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use