How inflammatory processes disrupt the functioning of important enzymes in the liver cells thereby impairing the ability of the liver to perform its job of detoxifying foreign substances that come along with food, was explored by experts at the German Federal Institute for Risk Assessment (BfR) in Berlin. Liver, an important metabolic organ gets fatty and inflamed by a poor diet and other risk factors leading to chronic liver damage known as cirrhosis of the liver. An in vitro study was conducted by a team of researchers from the German Federal Institute for Risk Assessment (BfR) in Berlin to investigate how degenerative fattening and inflammation can impair the body's primary detoxification system. "The findings show that inflammatory processes, in particular, can disrupt the functioning of important enzymes in the liver cells," says Professor Dr. Andreas Hensel, President des BfR. "This seriously impairs the ability of the liver to perform its job of detoxifying foreign substances that are ingested with food." ‘The liver performs the job of detoxifying foreign substances that come along with food. Degenerative fattening and inflammation can impair the liver which is the body’s primary detoxification system.’ It is not yet fully clear how a fatty and inflamed liver affects the liver's ability to identify and break down foreign substances like chemicals or medication. In cooperation with the Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology in Stuttgart, the BfR researchers treated human liver cells with fatty acids as well as inflammation-promoting and foreign substances. This enabled them to simulate the conditions in the liver and to document how the cells respond. The main finding reported by the scientists in the Drug Metabolism and Disposition journal was that, while mere fattening of the liver cells did not have a major impact on detoxification functions, this changed when they introduced inflammatory processes. It is therefore likely that the ability to render foreign substances harmless is significantly impaired in the presence of inflammation due to a fatty liver.Source: Eurekalert << New insights into the Study of Congo Fever Is Frailty Associated to Future Cardiovascular Disease and M... >> Recommended Reading Fatty Liver Disease: A Growing Health Problem in India Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India. READ MORE Fibroscan for Fatty Liver Cirrhosis and Fibrosis Recently, Fibroscan has incorporated the noninvasive Controlled Attenuation Parameter technique to estimate the degree of fatty infiltration in the liver. READ MORE Risk of Fatty Liver Disease in Low and High Birth Weight Babies Low-birth weight and high-birth weight were both associated with the severity of liver disease, but in different ways READ MORE Our Chairs are Slowly Killing Us As Prolonged Sitting Is Linked With Fatty Liver Disease Our body is designed to move and it is not surprising that sedentary behavior, characterized by low muscle activity, has a direct impact on physiology. READ MORE Current Treatments for Liver Cancer Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. READ MORE Hepatitis A Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. Hepatitis A vaccine is available that is 95% effective in preventing the disease. READ MORE Living Donor Liver Transplant: What Are the Risks? The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk of morbidity is anywhere between 1.3% (in highly experienced centers) to 60%. READ MORE Milk Thistle Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication milk thistle is used in cases of liver diseases. READ MORE Wilson's Disease This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before other organs. READ MORE Most Popular on Medindia Noscaphene (Noscapine) Loram (2 mg) (Lorazepam) How to Reduce School Bag Weight - Simple Tips More News on: Hepatitis ALiverWilson's DiseaseMilk ThistleCurrent Treatments for Liver CancerFatty Liver Disease: A Growing Health Problem in IndiaLiving Donor Liver Transplant: What Are the Risks?