About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Risk of Surgical Bleeding to Be Reduced by the Use of Recombinant Technology

by Medindia Content Team on August 13, 2007 at 4:36 PM
Font : A-A+

Risk of Surgical Bleeding to Be Reduced by the Use of Recombinant Technology

Recombinant technology can ease the surgeon mind by decreasing the risk of surgical bleeding during surgery according to a new research published in the August issue of the Journal of the American College of Surgeons. The Use of recombinant human thrombin (rh thrombin) stops bleeding in 95 percent of patients within 10 minutes with lower risks than current standard blood-clotting treatment.

At present commercially available plasma-derived bovine thrombin (thrombin) is used to improve clotting during surgical procedures and stop bleeding.

Advertisement

Each year, bThrombin is used to treat more than one million patients who undergo surgical procedures in the United States. However, approximately 20 percent of these patients develop antibodies against bovine coagulation factors that can cross-react with human coagulation proteins and possibly lead to adverse effects, including severe bleeding and thrombosis. Due to these safety concerns, rhThrombin was developed as an alternative to bThrombin.

"We constantly look for new ways to reduce risks in surgery and stopping surgical bleeding safely and effectively is of foremost interest to surgeons.
Advertisement

The results from this phase III trial show that we can stop bleeding in 95 percent of patients within 10 minutes and do so without introducing foreign proteins that can carry greater risk of development of antibodies," said William C. Chapman, MD, FACS, Department of Surgery, Washington University, St. Louis (MO) School of Medicine.

"I'm most encouraged by the increasing evidence that recombinant technology is safe and effective because it means that we may be able to avoid using blood or blood products from other people or animals and automatically diminish the risk of infection and the associated immunologic responses that have been noted in the past."

The randomized, double-blind comparative study included 411 patients who underwent surgical procedures at 34 U.S. medical centers across the country. One group of patients (n=206) was treated with bThrombin and a second group (n=205) was treated with rhThrombin, both of which were applied topically to the bleeding site(s) in combination with an absorbable gelatin sponge.

The primary endpoint was the time it took for hemostasis to occur, as measured by the incidence of hemostasis within 10 minutes. Secondary endpoints included the incidence and severity of adverse events and the incidence of antiproduct antibodies.

The study demonstrated that both rhThrombin and bThrombin had comparable efficacy, with 95 percent of patients in each treatment group achieving hemostasis within 10 minutes. The two treatments had similar safety profiles, although antibody development was significantly lower in patients treated with rhThrombin compared with bThrombin (1.5 percent versus 21.5 percent, respectively).



Source: Eurekalert
BIN/J
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Memory Loss - Can it be Recovered?
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
von Willebrand Disease Hemophilia 

Recommended Reading
Risk of Blood Clot in Arteries Increases If Chemotherapy is Combined With Bevacizumab
According to a study published online August 7 in the Journal of the National Cancer Institute show ...
Hemophilia
Hemophilia is a rare single gene, X- linked disorder, which tends to run in families....
von Willebrand Disease
von Willebrand's Disease (vWD) is an autosomal dominant inherited bleeding disorder that occurs from...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use