About Careers Internship MedBlog Contact us

Risk of Kidney Failure-related Death Takes a Dip

by Julia Samuel on December 15, 2017 at 12:14 PM
Risk of Kidney Failure-related Death Takes a Dip

Efforts to improve care have resulted in improved survival of those with renal failure who were usually at an early risk of death.

Although rates of early death have decreased over time in patients with kidney failure, it is unknown if improvements merely reflect parallel improvements in the general population. To investigate, a team led by Bethany Foster, MD, MSCE (Montreal Children's Hospital and the Research Institute of the McGill University Health Centre) and Benjamin Laskin, MD, MSCE (The Children's Hospital of Philadelphia) examined changes in the excess risk of early death--over and above the risk in the general population--among people treated for kidney failure in the United States.


Mortality Risk Assessment For All Age Groups

The analysis included 1,938,148 children and adults diagnosed with kidney failure from 1995 to 2013. The change over any 5-year interval between 1995 and 2013 in the excess risk of kidney failure-related death varied by age, with decreases from 12% for 65-year-olds to 27% for 0-14-year-olds.

The mortality rate of those dying from renal failure for all ages and both during treatment with dialysis and during time with a functioning kidney transplant reduced. The largest relative improvements observed for the youngest individuals with a functioning kidney transplant. Absolute decreases in excess kidney failure-related mortality were greatest for the oldest patients.

"We showed that all age groups have had significant improvements in mortality risk over the past 22 years. Some of the improvements were due to improved access to kidney transplantation and to longer survival of kidney transplants, but there were also improvements that can only be attributed to improvements in the care provided to people treated with dialysis and to those with kidney transplants," said Dr. Foster.

"This is important given the huge investment of resources in caring for these patients; we have shown that these investments have made a difference."

Dr. Foster noted that the investigators expected to find decreased mortality rates for all age groups except those in late adolescence and early young adulthood. This age group often has difficulty adhering to recommended treatments, and there is sometimes a breakdown in the continuity of care when young people are transferred from a pediatric healthcare facility to an adult care facility.

"We discovered that young people in this age group had no improvements in mortality risk between 1995 and 2006, unlike all other age groups, but started to have significant improvements after 2006," said Dr. Foster. "This may be because healthcare professionals became more sensitized to these problems in the early 2000s and have changed the way they care for these young people."

Although individuals with kidney failure still have much higher risks of early death than people in the general population, it appears that the gap is gradually closing. "One of the best ways to improve health in people with kidney failure is for them to get a kidney transplant, and the limited supply of suitable organs is still a major impediment to more progress in outcomes for people with kidney failure, Dr. Foster said. "Everyone needs to think about organ donation and sign their organ donor cards."

Source: Eurekalert
Font : A-A+



Recommended Readings

Latest Research News

Disrupted Circadian Rhythm Elevates the Risk of Parkinson's Disease
Trouble with sleep and the body's clock may increase your risk for Parkinson's, as per a new study.
A Wake-Up Call for Women  Hot Flashes Could Point to Alzheimer's Risk
New study uncovers a link between nocturnal hot flashes and Alzheimer's risk in menopausal women, suggesting a potential biomarker.
Breakthrough Brain-Centered Approach Reduces Chronic Back Pain
Our discovery revealed that a minority of individuals attributed their chronic pain to their brain's involvement.
New Statement to Protect Athletes' Health Published
Relative Energy Deficiency in Sport syndrome is overlooked by athletes and can be worsened by 'sports culture' due to its perceived short-term performance benefits.
Brain Circuits That Shape Bedtime Rituals in Mice
New study sheds light on the intrinsic, yet often overlooked, role of sleep preparation as a hardwired survival strategy.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
Greetings! How can I assist you?MediBot

Risk of Kidney Failure-related Death Takes a Dip Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests