About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Resveratrol Boosts Chances Of Full Recovery From All Types Of Prostate Cancer

by VR Sreeraman on November 10, 2012 at 1:38 PM
Font : A-A+

 Resveratrol Boosts Chances Of Full Recovery From All Types Of Prostate Cancer

Researchers have time and again extolled the beneficial aspects of resveratrol, a compound found commonly in grape skins and red wine on human health. Now the same has been discovered to make the prostate tumor cells more susceptible to radiation treatment, increasing the chances of a full recovery from all types of prostate cancer, including aggressive tumors.

The compound has been previously shown to have several beneficial effects on human health, including cardiovascular health and stroke prevention.

Advertisement

"Other studies have noted that resveratrol made tumor cells more susceptible to chemotherapy, and we wanted to see if it had the same effect for radiation therapy," said Michael Nicholl, an assistant professor of surgical oncology in the MU School of Medicine.

"We found that when exposed to the compound, the tumor cells were more susceptible to radiation treatment, but that the effect was greater than just treating with both compounds separately," he stated.
Advertisement

Prostate tumor cells contain very low levels of two proteins, perforin and granzyme B, which can function together to kill cells. However, both proteins need to be highly "expressed" to kill tumor cells.

In his study, when Nicholl introduced resveratrol into the prostate tumor cells, the activity of the two proteins increased greatly. Following radiation treatment, Nicholl found that up to 97 percent of the tumor cells died, which is a much higher percentage than treatment with radiation alone.

"It is critical that both proteins, perforin and granzyme B, are present in order to kill the tumor cells, and we found that the resveratrol helped to increase their activity in prostate tumor cells," Nicholl said.

"Following the resveratrol-radiation treatment, we realized that we were able to kill many more tumor cells when compared with treating the tumor with radiation alone. It's important to note that this killed all types of prostate tumor cells, including aggressive tumor cells," he added.

Resveratrol is present in grape skins and red wine and available over-the-counter in many health food sections at grocery stores. However, the dosage needed to have an effect on tumor cells is so great that many people would experience uncomfortable side effects.

"We don't need a large dose at the site of the tumor, but the body processes this compound so efficiently that a person needs to ingest a lot of resveratrol to make sure enough of it ends up at the tumor site. Because of that challenge, we have to look at different delivery methods for this compound to be effective," Nicholl noted.

Nicholl said that the next step would be to test the procedure in an animal model before any clinical trials can be initiated.

His studies were published in the Journal of Andrology and Cancer Science.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Baldness can be Cured and Prevented: let us see How!
Drinking Beer or Wine Every Day Could Cause Age-related Diseases
Low-Calorie Diet for Diabetes
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Prostate Cancer Cancer and Homeopathy Anti-ageing and Benefits of Red Wine Trans-Urethral Resection of the Prostate Prostate Cancer Facts Cancer Facts Cancer Tattoos A Body Art Prostate Cancer: Treatment Options Prostate Specific Antigen [PSA] 

Most Popular on Medindia

Vent Forte (Theophylline) Find a Doctor Drug Interaction Checker Iron Intake Calculator Sanatogen Drug - Food Interactions Daily Calorie Requirements Loram (2 mg) (Lorazepam) The Essence of Yoga Diaphragmatic Hernia
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use