Depending on the molecular and genetic information from the tumors, breast cancer can be divided into 4 major subtypes. Each subtype is associated with different prognosis and should be taken into consideration when making treatment decisions. In this issue of the Journal of Clinical Investigation, Rebecca Cook and colleagues at Vanderbilt University, found that expression of an oncogene, ERBB3, was enhanced in luminal breast cancers compared to other breast cancer subtypes. Addition of the ERBB3 protein to cultured luminal breast cancer cells increased the growth of the cells; however, depletion of this protein with an antibody promoted cancer cell death, and decreased tumor growth in vitro. The authors also demonstrated that ERBB3 was upregulated in luminal tumor samples and in cancer cell cultures that were treated with the cancer drug fulvestrant. Furthermore, the authors found that fulvestrant treatment in combination with anti-ERBB3 decreased both tumor cell survival and growth. These data suggests that ERBB3 could be a target for treatment of fulvestrant resistant breast cancers. Source: Eurekalert << Effective Role Models for Infection Prevention Hamper Effic... Research Elaborates on Comparison of Antibody Levels for 4 ... >> Recommended Reading Breast Cancer Screening using Mammogram Breast cancer if detected early can be completely cured. Mammography is used to screen women for breast cancer. READ MORE Breast Cancer during Pregnancy Management of breast cancer during pregnancy or pregnancy associated breast cancer requires special consideration to avoid harm to the fetus. READ MORE Breast Cancer Management: Advances The crab that invades the breast is no more a fear factor with all the advancements that medical science and customized protocols can fight breast cancer. the recent developments in the management of breast cancer. READ MORE Breast Cancer - Prevention and Management with Lifestyle Changes Lifestyle choices may or may not cause breast cancer but healthy lifestyle changes can open up avenues beyond breast cancer. Good habits will allow one to fight breast cancer and to live with dignity. READ MORE Breast Cancer Management: Advances The crab that invades the breast is no more a fear factor with all the advancements that medical science and customized protocols can fight breast cancer. the recent developments in the management of breast cancer. READ MORE Breast Enhancement Oil Breasts contain mammary glands which produce and secrete milk for feeding and nourishing babies. Though both men and women have mammary glands the male breasts differ from female ones as there is no physiological function for milk production in males. READ MORE Breast Lumps Most breast lumps are caused by hormonal changes in a woman and may not be cancerous. Common causes of breast lumps include fibroadenosis, breast cancer, breast cyst. READ MORE Breast Lumps-Screening Breast lumps must never be neglected but instead be subjected to medical examination to rule out cancer. READ MORE Breasts - Structures and Types Different stages of breast development in women and an in-depth look at the breast/bust and its structure. READ MORE Mastitis Mastitis is a common cause of tenderness, swelling and pain in breast, owing to inflammation in the mammary gland, Breast infection may occur in some cases. READ MORE Tumor Markers For Cancer Diagnosis and Prognosis An ideal tumor marker for a cancer should be specific to that cancer and not generate false positive results. READ MORE Most Popular on Medindia Blood Pressure Calculator Find a Hospital Fongitar (Zinc Pyrithionone) More News on: MastitisReiki and Pranic HealingBreasts - Structures and TypesTumor Markers For Cancer Diagnosis and PrognosisBreast LumpsBreast Lumps-ScreeningBreast Cancer Management: AdvancesBreast Enhancement Oil
Depending on the molecular and genetic information from the tumors, breast cancer can be divided into 4 major subtypes. Each subtype is associated with different prognosis and should be taken into consideration when making treatment decisions. In this issue of the Journal of Clinical Investigation, Rebecca Cook and colleagues at Vanderbilt University, found that expression of an oncogene, ERBB3, was enhanced in luminal breast cancers compared to other breast cancer subtypes. Addition of the ERBB3 protein to cultured luminal breast cancer cells increased the growth of the cells; however, depletion of this protein with an antibody promoted cancer cell death, and decreased tumor growth in vitro. The authors also demonstrated that ERBB3 was upregulated in luminal tumor samples and in cancer cell cultures that were treated with the cancer drug fulvestrant. Furthermore, the authors found that fulvestrant treatment in combination with anti-ERBB3 decreased both tumor cell survival and growth. These data suggests that ERBB3 could be a target for treatment of fulvestrant resistant breast cancers. Source: Eurekalert << Effective Role Models for Infection Prevention Hamper Effic... Research Elaborates on Comparison of Antibody Levels for 4 ... >> Recommended Reading Breast Cancer Screening using Mammogram Breast cancer if detected early can be completely cured. Mammography is used to screen women for breast cancer. READ MORE Breast Cancer during Pregnancy Management of breast cancer during pregnancy or pregnancy associated breast cancer requires special consideration to avoid harm to the fetus. READ MORE Breast Cancer Management: Advances The crab that invades the breast is no more a fear factor with all the advancements that medical science and customized protocols can fight breast cancer. the recent developments in the management of breast cancer. READ MORE Breast Cancer - Prevention and Management with Lifestyle Changes Lifestyle choices may or may not cause breast cancer but healthy lifestyle changes can open up avenues beyond breast cancer. Good habits will allow one to fight breast cancer and to live with dignity. READ MORE Breast Cancer Management: Advances The crab that invades the breast is no more a fear factor with all the advancements that medical science and customized protocols can fight breast cancer. the recent developments in the management of breast cancer. READ MORE Breast Enhancement Oil Breasts contain mammary glands which produce and secrete milk for feeding and nourishing babies. Though both men and women have mammary glands the male breasts differ from female ones as there is no physiological function for milk production in males. READ MORE Breast Lumps Most breast lumps are caused by hormonal changes in a woman and may not be cancerous. Common causes of breast lumps include fibroadenosis, breast cancer, breast cyst. READ MORE Breast Lumps-Screening Breast lumps must never be neglected but instead be subjected to medical examination to rule out cancer. READ MORE Breasts - Structures and Types Different stages of breast development in women and an in-depth look at the breast/bust and its structure. READ MORE Mastitis Mastitis is a common cause of tenderness, swelling and pain in breast, owing to inflammation in the mammary gland, Breast infection may occur in some cases. READ MORE Tumor Markers For Cancer Diagnosis and Prognosis An ideal tumor marker for a cancer should be specific to that cancer and not generate false positive results. READ MORE Most Popular on Medindia Blood Pressure Calculator Find a Hospital Fongitar (Zinc Pyrithionone) More News on: MastitisReiki and Pranic HealingBreasts - Structures and TypesTumor Markers For Cancer Diagnosis and PrognosisBreast LumpsBreast Lumps-ScreeningBreast Cancer Management: AdvancesBreast Enhancement Oil