About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Residual Breast Cancer in Lymph Nodes After Chemotherapy Detected By Less Invasive Surgery

by Rukmani Krishna on October 13, 2013 at 11:59 PM
Font : A-A+

 Residual Breast Cancer in Lymph Nodes After Chemotherapy Detected By Less Invasive Surgery

After chemotherapy to determine if any cancer remains, most patients whose breast cancer has spread to their lymph nodes have most of the lymph nodes in their armpit area removed. A study conducted through the American College of Surgeons Oncology Group and led by Judy Boughey, M.D., a breast surgeon at Mayo Clinic, shows that a less-invasive procedure known as sentinel lymph node surgery successfully identified whether cancer remained in lymph nodes in 91 percent of patients with node-positive breast cancer who received chemotherapy before their surgery. In sentinel lymph node surgery, only a few lymph nodes, the ones most likely to contain cancer, are removed. The findings are published online in the Journal of American Medical Association.

"Since treatment with chemotherapy before surgery can eliminate cancer in the lymph nodes in some patients, we were interested in evaluating whether sentinel lymph node surgery could successfully identify whether cancer remained in the lymph nodes after chemotherapy," says Dr. Boughey. Removing only a few lymph nodes reduces the risk of surgical complications such as numbness and arm swelling, she says.

Advertisement

Researchers studied 756 women with node-positive breast cancer who received chemotherapy as an initial treatment. Of study participants, 637 patients had both sentinel lymph node and axillary lymph node surgery. Sentinel lymph node surgery correctly identified whether cancer lingered in 91 percent of patients, including 255 patients with node-negative breast cancer and 382 patients with continuing node-positive disease.

Researchers also found that 40 percent of the patients had complete eradication of the
cancer from the lymph nodes. The study had a false-negative rate of 12.6 percent, and the false negative rate was significantly lower with the use of dual tracers (blue dye and radiolabeled colloid) to identify the sentinel lymph nodes. Also, when more than two sentinel nodes were removed, the false-negative rate was less than 10 percent. Dr. Boughey says that technical factors in surgery are important to help ensure correct staging, especially in the setting of patients who have received chemotherapy prior to surgery.
Advertisement

She anticipates that with appropriate patient selection, less extensive axillary surgery can be used for women who have the disease in their lymph nodes successfully eradicated by chemotherapy.

The study was conducted through the American College of Surgeons Oncology Group, part of the Alliance for Clinical Trials in Oncology, and funded by the National Cancer Institute.

Source: Newswise
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Good Nutrition Linked to Better Mental Health in School Children
Convulsions / Seizures / Fits - Symptom Evaluation
World Heart Day 2021 -
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Breast Biopsy Pagets disease of the breast Mastitis Cancer and Homeopathy Chronic Lymphocytic Leukemia Hodgkins Lymphoma Non-Hodgkins Lymphoma Chemotherapy Chemotherapy Drugs 

Recommended Reading
Breast Cancer during Pregnancy
Management of breast cancer during pregnancy or pregnancy associated breast cancer requires special ...
Male Breast Cancer
Most cases of male breast cancer are diagnosed between the ages of 60 and 70 years. Treatment of ......
Screening for Breast Cancer with Clinical Breast Examination
Clinical breast examination is a simple and inexpensive method of detecting breast cancer ......
Breast Cancer - Prevention and Management with Lifestyle Changes
Lifestyle choices may or may not cause breast cancer but healthy lifestyle changes can open up ......
Breast Biopsy
Breast biopsy involves removing a sample of breast tissue to determine whether it is cancerous or .....
Chemotherapy
‘Chemo’ means medicine or ‘drug’; ‘therapy’ means ‘treatment’. Chemotherapy refers to the use of cy...
Chemotherapy Drugs
Chemotherapy drugs perform like ‘magic bullets’ to destroy cancer cells in the body....
Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia (CLL) is one of the most common types of adult leukemia and is consider...
Hodgkins Lymphoma
Hodgkins lymphoma or Hodgkins disease has the distinction of being the first cancer to be cured by c...
Mastitis
Mastitis is a common cause of tenderness, swelling and pain in breast, owing to inflammation in the ...
Non-Hodgkins Lymphoma
Non Hodgkins Lymphoma is a cancer that affects the lymph tissues. It is made up of a wide array of ....
Pagets disease of the breast
A detailed description of the Paget's disease of the breast, characteristic signs and symptoms, dete...
Women and Cancer
Cancer is one of the frequently talked about and most feared disease that falls under the genre of l...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use