Can cancer be choked to death? A team of American researchers has asked themselves the exact same question and are now trying to develop a technique to literally 'murder cancer'!
Dr. Ze'ev Ronai, who is leading the research project at the Burnham Institute for Medical Research, has found that tumors deprived of oxygen activate a transcription factor called HIF-1a, which help them compensate and survive.
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The researcher says that inhibiting HIF-1a can cause tumors to experience oxygen deprivation due to insufficient blood flow.
Dr. Ronai's laboratory has already shown proof of this concept by inhibiting PHD3, a regulator of HIF-1a.
He says that binding of short protein fragments to PHD3 results in HIF-1a degradation, and halts growth of metastatic tumors in mice.
He and his colleagues are presently trying to determine how small molecule compounds might accomplish the same task.
Source: ANI
TAN/M
He says that binding of short protein fragments to PHD3 results in HIF-1a degradation, and halts growth of metastatic tumors in mice.
He and his colleagues are presently trying to determine how small molecule compounds might accomplish the same task.
Source: ANI
TAN/M
Liver Cancer - Animation
Liver is the largest organ inside the human body. It performs 500 different functions and processes 720 liters of blood per day. The important functions of the liver, the development of liver cancer and it's symptoms are presented in this interactive.
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