About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Researchers Turn Tumor Suppressor into Anti-Cancer Target

by Bidita Debnath on December 5, 2013 at 11:33 PM
Font : A-A+

 Researchers Turn Tumor Suppressor into Anti-Cancer Target

Researchers show how in mice the elimination of the Cdh1 protein —a sub-unit of the APC/C complex, involved in the control of cell division—prevents cellular proliferation of rapidly dividing cells.

The researchers are from laboratory of Marcos Malumbres, who is head of the Spanish National Cancer Research Centre's (CNIO) Cell Division & Cancer Group, working alongside Isabel Fariñas' team from the University of Valencia.

Advertisement

The study got published in the journal Nature Communications. These results could accelerate the development of new therapies targeting cancer.

Malumbres's group had previously discovered that the inactivation of another APC/C protein, Cdc20, prevented cell division. These results caught the attention of pharmaceutical companies, who are already developing the first inhibitors from the complex. These molecules have caused controversy due to the possible side effects of blocking Cdh1, which is considered a tumour suppressor.
Advertisement

Manuel Eguren has analysed the biological consequences of Cdh1 elimination in rapidly dividing cells, as part of his doctoral research project in Malumbres's group; he focused on progenitors from the nervous system during embryonic development in mice.

Via a detailed biochemical and cell study, researchers have discovered that the absence of Cdh1 causes DNA damage in cells. This defect causes cell death and leads to alterations in the development of the nervous system such as hydrocephalus, characterised by abnormal accumulation of fluid on the brain.

"Our results solve the controversy about the possible side effects of APC/C inhibitors", says Malumbres, adding that: "we have shown in vivo that their elimination leads to the death of rapidly dividing cells".

IMPLICATIONS FOR TUMOUR TREATMENT

The study is now focused on proposing a precise strategy for specific tumour types. "It could work in glioblastomas given that our study is based on brain progenitors, but we believe it could be extended to include other tumour types", say the researchers.

The CNIO researchers show that cell defects caused by the inhibition of Cdh1 are independent of the presence of the p53 molecule, which is mutated in different types of tumours. "The therapeutic effect of inhibiting Cdh1 should even work in tumours that carry mutations in this molecule", says Malumbres.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Is COVID-19 Vaccination during Pregnancy Safe?
Sensory Processing Disorder (SPD)
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Tumor Markers For Cancer Diagnosis and Prognosis Top 10 Health Benefits of Cloves 

Recommended Reading
Endometrial Cancer Promoted By Epigenetic Silencing of the HAND2 Tumor Suppressor: Study
Epigenetic modification of the HAND2 gene plays a critical role in the development of endometrial .....
Aggressive Leukemia Might Be Fueled By Tumor Suppressor: Study
Blocking a protein normally credited with suppressing leukemia may be a promising therapeutic ......
Tumor Suppressor Gene Involved in Acute Myeloid Leukemia Discovered
University of Chicago Medicine Comprehensive Cancer Center (UCCCC) scientists have discovered the .....
Tumor Suppressor Needed for Neural Tumour Cells to Mature into Neurons
Previously, CHD5 was proposed as a tumour suppressor, which acts as a brake that prevents healthy .....
Top 10 Health Benefits of Cloves
Clove doesn’t just enhance the flavor of food, but, keeps your health in check by keeping diabetes, ...
Tumor Markers For Cancer Diagnosis and Prognosis
An ideal tumor marker for a cancer should be specific to that cancer and not generate false positive...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use