About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Researchers Study Role of Small Non-Coding RNA for the Development of Testicular Tumors

by Bidita Debnath on November 24, 2013 at 11:00 PM
Font : A-A+

 Researchers Study Role of Small Non-Coding RNA for the Development of Testicular Tumors

In Barcelona, Spain, researchers from the Bellvitge Biomedical Research Institute (IDIBELL) have studied the role of a peculiar class of small non-coding RNAs that are mainly expressed in the human male germline.

Whereas messenger RNAs transmit the genetic information required for protein synthesis, non-coding RNAs are functional molecules that are never translated into proteins and have important roles in diverse cellular processes. In human spermatozoa, these tiny RNAs are epigenetically regulated (by changes in the genome that do not alter the DNA sequence, such as DNA methylation) and play a critical role in male germline development. Importantly, these RNAs have also been detected in human cancer cells.

Advertisement

In a work published in the January 2014 issue of Epigenetics, which is entirely devoted to "Non-coding RNAs in Epigenetic Regulation," the researchers asked if in their natural functional context (the normal human testis) these small RNAs undergo aberrant epigenetic regulation, compromising their function and contributing to the transformation of cells into testicular tumor cells.

The reported data suggest that epigenetic disruption of an entire small non-coding RNA pathway in human testis is indeed a hallmark for the development of testicular tumors.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Sensory Processing Disorder (SPD)
First Dose of COVID-19 Vaccines May Improve Mental Health
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Testicular Self-Examination 

Recommended Reading
Severe Childhood Genetic Disorders Linked To Testicular Tumors In Older Fathers
Researchers say a rare form of testicular tumor might help explain why some diseases are more ......
Tumors Increase Upon Intake Of Copper
A number of pathological conditions, including cancer have been associated with copper imbalances....
Tumors Get Sensitized to PARP Inhibitors When Hormonal Environment in Endometrial Cancer Is Controlled
UCLA researchers have shown that modulating the hormonal environment in which endometrial cancers .....
Mechanism That Makes Ordinary Stem Cells Create Tumors Identified
The way in which changes in cell signaling can cause ordinary stem cells in the jaw to start ......
Testicular Self-Examination
A testicular self-examination (TSE) helps in detecting cancer of the testicles. Doctors recommend mo...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use