The phone will play out several of the screams submitted by people online, the BBC reported.
The test will monitor the durability of standard commercial components in space.
It will also test two new innovative propulsion systems.
The first - named Warp Drive (Water Alcohol Resisto-jet Propulsion De-orbit Re-entry Velocity Experiment) - uses the ejection of a water-alcohol mixture to provide thrust.
The second technology is pulsed plasma thrusters. These use an electric current to heat and evaporate a material, producing a charged gas that can then be accelerated in one direction in a magnetic field to push the satellite in the other direction.
The mission will see the so-called "smartphone-sat" - a world first - orbit the Earth for six months.
Weighing 4.3 kg (9.5lbs) and measuring 10cm by 30cm (4in by 12in), the satellite has been developed by the University of Surrey's Space Centre (SSC) and Surrey Satellite Technology (SSTL).
"This mission is a fantastic achievement and a great tribute to the hard work of the engineers involved," Sir Martin Sweeting, director of SSC, and also executive chairman of SSTL said.
At first, the Strand-1 satellite will be controlled by a standard onboard computer, but in phase two of the mission, a Google Nexus phone will take the reins - equipped with a number of special apps.
One of them, iTesa, is to record the magnitude of the magnetic field around the phone during orbit.
The 360 app will take pictures using the phone's built-in five megapixel camera, and will act as a method of establishing the satellite's position.
Images captured by the app will be posted on Facebook.
The Scream in Space app, developed by Cambridge University Space Flight, makes use of several screams that were submitted by visitors to the project's website.
At various points, the app will play videos of the screams and monitor if the phone's onboard speaker picks up the noise.
The screams set for intergalactic broadcast include this ear-busting effort from Year 6 at Chudleigh CE Community Primacy School and this very dramatic "nooooooo!" from Richard Barrington.