About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Researchers Invent a Test to Uncover Toxicity of Antidepressant

by Dr. Trupti Shirole on December 17, 2014 at 12:29 PM
Font : A-A+

 Researchers Invent a Test to Uncover Toxicity of Antidepressant

A sensitive toxicity test invented at the University of Utah could make it possible to detect toxicity problems early in pharmaceutical development so that fewer patients are given unsafe drugs.

The researchers ran their test on Paxil, an antidepressant that thousands of pregnant women used in the years before it was linked to an increased risk of birth defects. The test called the organismal performance assay, or OPA, uses untamed house mice - rather than docile, inbred laboratory strains - and subjects them to a relentless, Darwinian competition for food, shelter and mates much like they would face in the wild.

Advertisement

Mice exposed to the drug during development experienced multiple problems- males weighed less, had fewer offspring, dominated fewer territories and died at a higher rate; while females took longer to produce their first litters, had fewer pups and pups that were underweight. No reproductive side effects emerged until rodents took doses multiple times higher than those given to treat depression.

Lead author of the study biologist Shannon M. Gaukler said, "We are seeing effects at a dose that is close to human levels. And we are doing it exactly the way we need to determine if it presents a risk of harm to a developing fetus."
Advertisement

Owing to toxicity issues, about 1/3 of prescription drugs approved in the U.S. are withdrawn from the market or require added warning labels limiting their use. Detecting toxicity problems early in preclinical testing would not only protect patients from exposure to unsafe drugs, but also help pharmaceutical companies avoid wasting billions of dollars bringing drugs to market only to have them fail.

The study is published in 'Neurotoxicology and Teratology'.

Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Are Black Foods the New Superfood?
Ten Fruits for Diabetics
Natural Supplements Help Reverse Hair Loss during Menopause
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Adolescence Depression Varicocele Amyotrophic Lateral Sclerosis (ALS) Antidepressants Testicle Pain - Symptom Evaluation Ciguatera - Fish Poisoning 

Recommended Reading
Unsafe Drugs- nimesulide, Cisapride, Phenylpropanolamine Banned
After several years of debate regarding the safety of nimesulide, cisapride and phenylpropanolamine ...
Government Urged To Protect Canadians From Unsafe Drugs
Canada needs to modernize its pharmaceutical drug laws to ensure that new drugs as well as older ......
Drug Shortage Forces Postponement Of Executions in US
In the midst of a drug shortage that has already forced postponement of lethal injection executions ...
Drugs in Pregnancy and Lactation
During pregnancy & lactation a nutritious diet, suitable exercise, adequate rest and a tranquil ......
Amyotrophic Lateral Sclerosis (ALS)
Find out more about the degenerative disease- Amyotrophic lateral sclerosis....
Ciguatera - Fish Poisoning
Ciguatera is a type of food poisoning caused due to the consumption of fish infected with a marine t...
Testicle Pain - Symptom Evaluation
A sudden, severe pain in the testis may be due to testicular torsion. Testicles inside the scrotum a...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use