In a recent work, researchers analyzed the airway epithelia of healthy nonsmokers, healthy smokers and smokers with chronic obstructive pulmonary disease (COPD) for expression of so-called "molecular cancerization" features (i.e., the genes upregulated in lung cancer compared with nonmalignant adjacent tissue).
Shaykhiev and colleagues analyzed the large and small airway epithelia of healthy nonsmokers, healthy smokers and smokers with chronic obstructive pulmonary disease (COPD), which is typically caused by long-term smoking, for expression of so-called "molecular cancerization" features (i.e., the genes upregulated in lung cancer compared with nonmalignant adjacent tissue).
Shaykhiev and colleagues analyzed the large and small airway epithelia of healthy nonsmokers, healthy smokers and smokers with chronic obstructive pulmonary disease (COPD), which is typically caused by long-term smoking, for expression of so-called "molecular cancerization" features (i.e., the genes upregulated in lung cancer compared with nonmalignant adjacent tissue).
Researchers found significantly more cancer-like gene expression changes in the large airway epithelia of smokers than in those of nonsmokers. When analyzing the small airway epithelium, though, they did not find significant differences between healthy smokers and nonsmokers, but they did find significant overall upregulation of cancerization genes in smokers with COPD. Analysis of these genes in the large and small airway epithelia obtained from the same individuals revealed that molecular cancerization occurs more frequently in the large airway epithelium than in the small airway epithelium.
These findings could potentially lead to the development of a diagnostic test that would look for these genetic changes in susceptible individuals, the researchers suggested.
"Ideally, we would use these genes to do very routine analysis to determine which smokers or even nonsmokers are at risk for development of lung cancer," said Shaykhiev.
Source: Newswise
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