In a significant discovery, researchers at La Jolla Institute for Allergy and Immunology in United States have identified the histamine releasing factor (HRF) as a key molecule that could be targeted in potential cures for a number of allergies including asthma.
The study was led by Toshiaki Kawakami who said that HRF molecule played an important role in promoting asthma and other allergies.
The researchers identified two novel peptides (N19 and H3) as strong therapeutic candidates for blocking the HRF and IgE interactions.
Stating that HRF has long been suspected to play a part in various allergies, Kawakami said that until now, its exact purpose and mode of operation was not clear. "Based on our preliminary studies, we believe these HRF inhibitors may provide a new, innovative therapeutic avenue for the treatment of asthma and some allergies", Kawakami said. The study has been published in the Journal of Clinical Investigation.