About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Researchers Engineer Viruses to Target Only Cancer Cells

by Rajashri on October 29, 2008 at 2:40 PM
Font : A-A+

 Researchers Engineer Viruses to Target Only Cancer Cells

A method of controlling the viruses behind potential cancer therapeutics, so that they will not damage healthy tissues has been developed by Mayo Clinic researchers.

The researchers believe that such viruses can be restricted to specific tissues by engineering the virus's genetic sequence with the aid of microRNAs.

Advertisement

They say that the microRNAs destabilize the virus's genome, making it impossible for the virus to run amok.

"Our findings demonstrate a new tool for molecular medicine that should also help allay concern over the use of viruses as a therapeutic delivery system," Nature Medicine quoted Dr. Stephen Russell, Mayo physician-scientist and lead author of the study, as saying.
Advertisement

MicroRNAs are the nucleotide snippets that are encoded by genes, but don't end up as proteins. In many cases, they have a role in down-regulating different cellular genes.

The Mayo Clinic team say that they have been successful in engineering a virus to be responsive to microRNAs that are present in certain cell types, thereby redirecting it to recognize only cancer cells.

They say that the experimental mice that received the engineered virus were cured of established tumours, without suffering any ill effects.

The team say that the target sequences of microRNAs used in the study kept the virus from destroying muscle cells, while allowing viral replication to proceed in cancer cells.

That, according to the researchers, allowed the virus to completely cure mice with melanoma.

The researchers say microRNA target insertion may be a new way to make viruses safer for use in cancer therapy, and may lead to new methods of making safer vaccines.

Source: ANI
RAS/SK
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Parkinsons Disease Surgical Treatment Cancer Facts Cancer Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Immune Checkpoint Inhibitors for Cancer Treatment Non-Communicable Diseases 

Recommended Reading
Biopsy-Introduction
Encyclopedia section of medindia explains in brief Introduction To Biopsy...
Women and Cancer
Cancer is one of the frequently talked about and most feared disease that falls under the genre of ....
Liver Cancer - Animation
Liver is the largest organ inside the human body. It performs 500 different functions and processes ...
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Health Benefits of Dandelion Plant
What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health benefits. ...
Immune Checkpoint Inhibitors for Cancer Treatment
Immune checkpoint inhibitors are promising drugs to treat a variety of cancers and the FDA has appro...
Non-Communicable Diseases
Non-Communicable Diseases (NCDs) are a group of chronic non-infectious diseases which include Cardio...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use