Scientists have derived a collection of 3D cultures or "organoids" from tumors of cancer patients that closely replicate key properties of the original tumors.
These "organoid" cultures or a living "biobank" can help detect genetic changes associated with drug sensitivity and pave the way for personalized cancer treatment.
Association Between Nut Consumption and Risk of Colorectal Cancer in Women
Women who ate just one-ounce of serving of nuts more than two times per week had a 13% lower risk of colorectal cancer compared to those who rarely eat nuts.
Advertisement
"We believe that these organoids are an important new tool in the arsenal of cancer biologists and may ultimately improve our ability to develop more effective cancer treatments," explained senior study author Mathew Garnett, geneticist at the Wellcome Trust Sanger Institute, a non-profit organization situated outside Cambridge.
In recent years, scientists have developed organoid cell culture systems as an alternative approach to grow normal and diseased tissue in a dish.
![Supercomputer Watson Extends Cancer Insights to 14 New US Cancer Treatment Centers]( "Supercomputer Watson Extends Cancer Insights to 14 New US Cancer Treatment Centers")
Watson helps give targeted treatment to cancer patients by analyzing a patient's genetic makeup, and correlating that with research on other patients.
In contrast to cell lines, organoids display the hallmarks of the original tissue in terms of its 3D architecture, the cell types present and their self-renewal properties.
In the new study, the researchers grew 22 organoids derived from tumor tissue from 20 patients with colorectal cancer and then sequenced genomic DNA isolated from these cultures.
The genetic mutations in the organoid cultures closely matched those in the corresponding tumor biopsies and agreed well with previous large-scale analyses of colorectal cancer mutations.
"These findings confirm that the cultures faithfully capture the genomic features of the tumors from which they are derived as well as much of the genomic diversity associated with colorectal cancer," the authors noted.
To link drug sensitivity to genetic changes, the researchers next screened the responses of the organoids to 83 experimental and approved cancer drugs.
Given their diverse genetic profiles, the organoids displayed a range of sensitivities to the drugs.
"At some point in the future, this approach may be suitable for modeling individual patient response to cancer therapies to inform clinical treatment," Garnett noted.
Moving forward, the researchers plan to develop an organoid biobank for other tumor types.
The study appeared in the journal Cell.
Source: IANS
Supercomputer Watson Extends Cancer Insights to 14 New US Cancer Treatment Centers
Watson helps give targeted treatment to cancer patients by analyzing a patient's genetic makeup, and correlating that with research on other patients.
Advertisement
In contrast to cell lines, organoids display the hallmarks of the original tissue in terms of its 3D architecture, the cell types present and their self-renewal properties.
In the new study, the researchers grew 22 organoids derived from tumor tissue from 20 patients with colorectal cancer and then sequenced genomic DNA isolated from these cultures.
The genetic mutations in the organoid cultures closely matched those in the corresponding tumor biopsies and agreed well with previous large-scale analyses of colorectal cancer mutations.
"These findings confirm that the cultures faithfully capture the genomic features of the tumors from which they are derived as well as much of the genomic diversity associated with colorectal cancer," the authors noted.
To link drug sensitivity to genetic changes, the researchers next screened the responses of the organoids to 83 experimental and approved cancer drugs.
Given their diverse genetic profiles, the organoids displayed a range of sensitivities to the drugs.
"At some point in the future, this approach may be suitable for modeling individual patient response to cancer therapies to inform clinical treatment," Garnett noted.
Moving forward, the researchers plan to develop an organoid biobank for other tumor types.
The study appeared in the journal Cell.
Source: IANS
Advertisement
 Use of Statins Among Lung Cancer Patients Reduces Risk of Death from the DiseaseWhile such findings are encouraging, researchers warn that the magnitude of the association was relatively small, as it is with all observational studies. | Advertisement
|
Advertisement
Recommended Readings
Latest Cancer News
Shorter radiation course is just as good as the regular one for women choosing breast reconstruction after mastectomy, saving time and money.
HAMMR's small size permits minimally invasive implantation, monitoring cancer status, and dynamically adjusting immunotherapy, akin to a glucose monitor.
The combination of the personalized cancer vaccine with ACT led to ovarian cancer control in few patients within a span of three months, stated study results.
Uncovering key kinases in tumor growth and invasion is crucial for improving targeted therapies in advanced-stage colorectal cancer.
The study findings validate metal-enhanced photo-oxidation for future metal-based anticancer drugs.
