Organoids cultures or a living biobank can help detect genetic changes associated with drug sensitivity and pave the way for personalized cancer treatment.
Association Between Nut Consumption and Risk of Colorectal Cancer in Women
Women who ate just one-ounce of serving of nuts more than two times per week had a 13% lower risk of colorectal cancer compared to those who rarely eat nuts.
Women who ate just one-ounce of serving of nuts more than two times per week had a 13% lower risk of colorectal cancer compared to those who rarely eat nuts.
In recent years, scientists have developed organoid cell culture systems as an alternative approach to grow normal and diseased tissue in a dish.
In contrast to cell lines, organoids display the hallmarks of the original tissue in terms of its 3D architecture, the cell types present and their self-renewal properties.
Supercomputer Watson Extends Cancer Insights to 14 New US Cancer Treatment Centers
Watson helps give targeted treatment to cancer patients by analyzing a patient's genetic makeup, and correlating that with research on other patients.
Watson helps give targeted treatment to cancer patients by analyzing a patient's genetic makeup, and correlating that with research on other patients.
The genetic mutations in the organoid cultures closely matched those in the corresponding tumor biopsies and agreed well with previous large-scale analyses of colorectal cancer mutations.
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Famous Australian Actor Carrie Bickmore Calls for Brain Cancer Support
Australian TV personalities extended their support after Carrie Bickmore shared her experience of living with her husband who died of brain cancer.
Australian TV personalities extended their support after Carrie Bickmore shared her experience of living with her husband who died of brain cancer.
To link drug sensitivity to genetic changes, the researchers next screened the responses of the organoids to 83 experimental and approved cancer drugs.
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Use of Statins Among Lung Cancer Patients Reduces Risk of Death from the Disease
While such findings are encouraging, researchers warn that the magnitude of the association was relatively small, as it is with all observational studies.
While such findings are encouraging, researchers warn that the magnitude of the association was relatively small, as it is with all observational studies.
"At some point in the future, this approach may be suitable for modeling individual patient response to cancer therapies to inform clinical treatment," Garnett noted.
Moving forward, the researchers plan to develop an organoid biobank for other tumor types.
The study appeared in the journal Cell.
Source-IANS
