About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Researchers Better Understand Parkinson's Disease Now With Naturally Occurring Brain Mechanism

by Tanya Thomas on February 14, 2011 at 7:25 AM
Font : A-A+

 Researchers Better Understand Parkinson's Disease Now With Naturally Occurring Brain Mechanism

A University of South Florida study has suggested that targeting the neuroinflammatory causes Parkinson's disease with a brain chemical signal may lead to better understanding of the disease and pave way for better therapies.

Brain inflammation has been clearly shown in PD, and the brain's microglia-small cells that regulate the chemical environment of neural cells-play a role in the inflammatory process and disease progression, said study lead author Paula C. Bickford.

Advertisement

"In the brain, one aspect of immune regulation occurs through neurons. Immune cells called microglia can damage neurons by producing bioactive molecules. On the other hand, a neuron-generated signaling chemical, or fractalkine, also called CX3CL1, suppresses the activation of microglia.

"Our study examined whether adding CX3CL1 beyond normal levels could decrease microglial activation and, therefore, play a neuroprotective role by helping prevent the loss of important neural cells in an animal model of Parkinson's disease," said Bickford.
Advertisement

Using rat models of Parkinson's with known inflammatory components, the researchers added CX3CL1 in varying doses and found that, in all cases, CX3CL1 reduced the loss of dopamine cells.

The loss of dopamine rich nerve fibers in the brain is a key aspect of Parkinson's, leading to movement-related symptoms such as tremors, muscle stiffness, balance problems and slowness.

"This suggests that the communication between neurons and glial cells may play a role in Parkinson's disease neurodegeneration," said Carmelina Gemma, co-lead scientist for the study.

The findings have been published online in the Journal of Neuroinflammation.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge About Chromosomes?
Eating During Sunlight Hours Minimizes Mood Vulnerabilities
Know More About the Digestive System
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Parkinsons Disease Surgical Treatment Brain Brain Facts Ataxia Nutritional Management of Parkinsons disease Language Areas in The Brain Ways to Improve your Intelligence Quotient (IQ) 

Most Popular on Medindia

Blood Pressure Calculator Selfie Addiction Calculator Diaphragmatic Hernia Hearing Loss Calculator Noscaphene (Noscapine) A-Z Drug Brands in India Post-Nasal Drip Blood Donation - Recipients Color Blindness Calculator How to Reduce School Bag Weight - Simple Tips
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Researchers Better Understand Parkinson's Disease Now With Naturally Occurring Brain Mechanism Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests