About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Researchers Are Exploring the Cause of Sudden Unexplained Death in Epilepsy

by Rukmani Krishna on March 28, 2013 at 11:28 PM
Font : A-A+

 Researchers Are Exploring the Cause of Sudden Unexplained Death in Epilepsy

Dravet syndrome (DS) is a form of infantile-onset, treatment-resistant epilepsy. It is caused by a mutation in the gene encoding a voltage-gated sodium channel, SCN1A. DS patients have a 30-fold increased risk of dying from sudden unexplained death in epilepsy (SUDEP) compared to patients with other forms of pediatric-onset epilepsy.

In this issue of the Journal of Clinical Investigation, Franck Kalume and colleagues at the University of Washington characterized SUDEP in a mouse model of DS. Observation using video, electroencephalography, and electrocardiography revealed that a prolonged slowing of the heart beat preceded SUDEP in mice.

Advertisement

Treatment with with drugs that reduce activity in the parasympathetic nervous system reduced the incidence of SUDEP, suggesting that mortality results from seizure-related parasympathetic hyperactivity. In a companion Attending Physician, Orrin Devinsky and colleagues discuss how these results could relate to SUDEP in human DS patients.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Epilepsy Febrile Fits / Febrile Convulsions Death Facts Bereavement Reye’s Syndrome 

Recommended Reading
Epilepsy
Fits or convulsions or Epilepsy is characterized by recurrent, involuntary seizures and is ......
Neurocysticercosis
Neurocysticercosis or Cysticercosis of brain is the most common cause of epilepsy and the most ......
Convulsions
Seizure or a convulsion is a result of abnormal electrical activity in the brain. If there are two ....
Bereavement
Bereavement refers to grief, pain and sadness following the loss of a loved one, especially during t...
Febrile Fits / Febrile Convulsions
High fever in kids can cause convulsions and are called febrile fits that do not include the seizure...
Reye’s Syndrome
Reye's syndrome is a medical emergency chiefly affecting children and teenagers and is marked by the...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use