About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Researcher Studying Fruit Flies to Identify Gene That Becomes Active After Sleep Deprivation

by Kathy Jones on May 11, 2013 at 6:32 PM
Font : A-A+

 Researcher Studying Fruit Flies to Identify Gene That Becomes Active After Sleep Deprivation

A Washington University School of Medicine researcher is currently observing fruit flies in order to identify a human gene that becomes more active after sleep deprivation.

For years, Paul Shaw, PhD, has used what he learns in fruit flies to look for markers of sleep loss in humans.

Advertisement

Shaw reverses the process in a new paper, taking what he finds in humans back to the flies and gaining new insight into humans as a result - identification of a human gene that is more active after sleep deprivation.

"I'm calling the approach cross-translational research," Shaw, associate professor of neurobiology said.

"Normally we go from model to human, but there's no reason why we can't take our studies from human to model and back again," he said.
Advertisement

Shaw and his colleagues plan to use the information they are gaining to create a panel of tests for sleep loss.

The tests may one day help assess a person's risk of falling asleep at the wheel of a car or in other dangerous contexts.

Scientists have known for years that sleep disorders and disruption raise blood serum levels of interleukin 6, an inflammatory immune compound.

Shaw showed that this change is also detectable in saliva samples from sleep-deprived rats and humans.

Based on this link, Shaw tested the activity of other immune proteins in humans to see if any changed after sleep loss.

The scientists took saliva samples from research participants after they had a normal night's sleep and after they stayed awake for 30 hours.

They found two immune genes whose activity levels rose during sleep deprivation.

The researchers identified genes in the fruit fly that were equivalent to the human genes, but their activity didn't increase when flies lost sleep.

When they screened other, similar fruit fly genes, though, the scientists found one that did.

"We've seen this kind of switch happen before as we compared families of fly genes and families of human genes," Shaw said.

"Sometimes the gene performing a particular role will change, but the task will still be handled by a gene in the same family," he said.

When the scientists looked for the human version of the newly identified fly marker for sleep deprivation, they found ITGA5 and realized it hadn't been among the human immune genes they screened at the start of the study.

Testing ITGA5 activity in the saliva samples revealed that its activity levels increased during sleep deprivation.

The findings are published in the journal PLOS One.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
Long-Term Glycemic Control - A Better Measure of COVID-19 Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
DNA Finger Printing Snoring Sleep Disorder : Restless Legs Syndrome Sleep Disorder: Sleepwalking Periodic Limb Movement Disorder REM Behavior Disorder Sleep Disturbances In Women Sleep Insomnia Obstructive Sleep Apnea 

Recommended Reading
Sleep Disorder : Restless Legs Syndrome
Restless legs syndrome (RLS) causes - An urge to move, usually due to uncomfortable sensations ......
Obstructive Sleep Apnea
Obstructive sleep apnea should be suspected in overweight middle aged adults who snore loudly and ....
Circadian Rhythm Sleep Disorders
Circadian rhythm (also known as sleep/wake cycle or the body clock) is a biological process that ......
Ageing and Sleep
Sleep is a barometer of good health in the elderly. Sleep problems in the elderly are controlled by ...
DNA Finger Printing
DNA fingerprinting is a technique which helps forensic scientists and legal experts solve crimes, id...
Insomnia
Difficulty in initiating and maintaining sleep is known as insomnia. It is a symptom that occurs due...
Periodic Limb Movement Disorder
Periodic limb movement disorder (PLMD) is a sleep disorder which causes repetitive cramping or jerki...
REM Behavior Disorder
REM Behavior Disorder (RBD) is a sleep disorder in which the person acts out dramatic or violent dre...
Sleep
Sleep is a behavioral state of restricted physical activity. It is controlled by our internal biolo...
Sleep Disorder: Sleepwalking
Sleepwalking or “Somnambulism,” is a type of parasomnia and has medico-legal implications...
Sleep Disturbances In Women
The physical, emotional and hormonal changes that occur in women during puberty, menstrual cycle, pr...
Snoring
Turbulent airflow causes tissues of the nose and throat to vibrate and the noise produced by these v...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use