About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Research Shows How Alzheimer's Plaques Lead to Loss of Nitric Oxide in Brain

by Sheela Philomena on January 13, 2011 at 1:03 PM
Font : A-A+

Research Shows How Alzheimer's Plaques Lead to Loss of Nitric Oxide in Brain

The process by which the Alzheimer's disease interact with certain cellular proteins to inhibit normal signals that aids in the maintenance of blood flow to the brain, discovered by a researcher at the University of Pittsburgh School of Medicine.

Levels of nitric oxide (NO) - a signaling molecule that helps regulate blood flow, immune and neurological processes - are known to be low in the brains of people who have Alzheimer's disease, but the reason for that hasn't been clear, said study co-author Jeffrey S. Isenberg, associate professor, Division of Pulmonary, Allergy, and Critical Care Medicine, Pitt School of Medicine.

Advertisement

"Our research sheds light on how that loss of NO might happen, and reveals biochemical pathways that drug discoverers might be able to exploit to find new medicines for Alzheimer's," he said.

"There is evidence that suggests enhancing NO levels can protect neurons from degenerating and dying."

The researchers, led by first author Thomas Miller and senior author David D. Roberts, both of the Laboratory of Pathology in NIH's National Cancer Institute (NCI), found in mouse and human cell experiments that amyloid-beta, the main component of the plaques that accumulate on brain cells in Alzheimer's, binds to a cell surface receptor called CD36, which causes decreased activity of the enzyme soluble guanylate cyclase to reduce NO signaling. But that inhibitory effect required the presence of and interaction with CD47, another cell surface protein, indicating that additional steps in the pathway remain to be identified.
Advertisement

"It's possible that an agent that could block either CD36 or CD47 could slow the progress of neuronal degeneration in Alzheimer's by protecting the production of NO in the brain," Isenberg said.

"Importantly, we have already identified therapeutic agents that can interrupt the inhibitory signal induced by these interactions to maximize NO production, signaling and sensitivity."

The findings have been published in Public Library of Science One.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Alzheimers Disease Creutzfeldt-Jakob Disease Diet and Alzheimer´s Disease Peyronie´s Disease Genetics of Alzheimer´s disease Mini-Mental Scale (Cognitive Function Test) 

Most Popular on Medindia

Vent Forte (Theophylline) Drug Interaction Checker Sanatogen Selfie Addiction Calculator The Essence of Yoga Find a Doctor Find a Hospital Noscaphene (Noscapine) Sinopril (2mg) (Lacidipine) Drug - Food Interactions
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Research Shows How Alzheimer's Plaques Lead to Loss of Nitric Oxide in Brain Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests