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Research Sheds Light on Parental Controls on Embryonic Development

by Kathy Jones on December 3, 2011 at 9:36 PM
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 Research Sheds Light on Parental Controls on Embryonic Development

It is common knowledge that when a sperm fertilizes an egg, each contributes a set of chromosomes to the resulting embryo. At these very early stages the embryo is called a zygote.

Early on, zygotic genes are inert, so embryonic development is largely controlled by parental factors. The activation of the zygotic genome therefore represents an important transition toward a more autonomous mode of embryonic development, and has been the subject of much speculation and scrutiny. Now, a new study published by Cell Press on December 1st in the journal Developmental Cell suggests that the reach of parental control in the embryo may be longer than we thought.

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It is known that in sperm, certain DNA-binding proteins called histones are modified in special ways, at specific genes that are switched on in the embryo. Could these marks actually be passed on from sperm to embryo, to determine how genes are controlled in the offspring? Or are they erased for the zygote to start anew? In a collaborative effort between multiple institutions lead by Prof. Philippe Collas from the University of Oslo and the Norwegian Center for Stem Cell Research, scientists examined the marks on histones in fish zygotes before and after zygotic genome activation and found evidence that many of the same histone marks seen in sperm are also present in the zygote before genome activation... and these same marks appear to predict which genes will be activated later during development.

Thus, it seems that there is a "pre-pattern," made with direct input from the parents, guiding development even after zygotic genome activation. As suggested by Prof. Collas in the study, "early developmental instructions may be provided by specific marking of the sperm and egg genomes by modified histones, which may be transmitted to the embryo through fertilization."

This study was a collaboration between the Norwegian School of Veterinary Science, the University of Birmingham, the Genome Institute of Singapore, the University of Oslo and the Norwegian Center for Stem Cell Research.
Source: Eurekalert
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