About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Research Says Good Cholesterol can Help Fight Heart Disease

by Kathy Jones on March 29, 2012 at 10:01 PM
Font : A-A+

 Research Says Good Cholesterol can Help Fight Heart Disease

The role of high density lipoprotein (HDL) in protecting against heart disease has been confirmed by a University of Amsterdam cardiologist.

John Kastelein made his finding while examining a patient who was brought into emergency at an Amsterdam hospital after he had collapsed with a heart attack.

Advertisement

The 36-year-old man was tall and lean, non-smoking and physically fit.

"All his coronary arteries were terribly obstructed and he got operated on right away," Sydney Morning Herald quoted Professor Kastelein, now chairman of the genetics of cardiovascular disease at the University of Amsterdam, as saying.
Advertisement

The damage was so severe that seven of his arteries had to be bypassed.

"In young people, surgeons often use the mammary artery that runs parallel to the breastbone on both sides, to patch into the heart,'' he said.

"That artery never has atherosclerosis [blockages] so the surgeon was totally amazed to find both mammary artery walls had become diseased," he explained.

Investigations revealed the patient, Piet Snoek, had a gene mutation that blocked all production of HDL.

His case "completely convinced" Professor Kastelein that the protective effects of HDL were as significant a part of the heart disease story as the well-known damage wrought by low density lipoprotein "bad" cholesterol.

He set out to demonstrate a heresy: that raising cholesterol could help the heart, provided the cholesterol in question was HDL.

"Every manipulation that raises HDL in a mouse or a rabbit is beneficial," said Professor Kastelein, who will deliver a plenary address in Sydney on Monday at the International Symposium on Atherosclerosis.

Fifteen years later, Snoek is still alive. Professor Kastelein and colleagues have used drugs to completely eliminate LDL from his body, compensating for the absence of HDL.

"Heart disease is the result of the balance of these two," he said.

Several drug companies have begun synthesising HDL - which attaches to cells that mop up LDL, steering them into the circulation - following a heart attack.

"We have shown we can mobilise cholesterol from the arterial wall. We can move amounts of cholesterol that in my mind are very clinically significant," Professor Kastelein said.

The next step is to use heart scans to evaluate whether this reverses artery damage.

Philip Barter, of the Heart Research Institute in Sydney, said raising HDL had ''the potential to be as important on top of [cholesterol-lowering] statins as statins were on nothing".

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Get Involved and Stand Up for Human Rights on Human Rights Day 2022
Coronary Artery Bypass Grafting
Macronutrients Calculator for Weight Loss
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cholesterol High Cholesterol Cardiac Catheterization Heart Attack Air travel: To fly or not to fly Diet Lifestyle and Heart Disease Body Mass Index Silent Killer Diseases Cholesterol - The Enigma Chemical Liposuction 

Most Popular on Medindia

Accident and Trauma Care Selfie Addiction Calculator Indian Medical Journals Find a Hospital Vent Forte (Theophylline) How to Reduce School Bag Weight - Simple Tips Blood Donation - Recipients Post-Nasal Drip Find a Doctor Blood - Sugar Chart
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Research Says Good Cholesterol can Help Fight Heart Disease Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests