About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Research Says Down's Chromosome Causes Genome-Wide Disruption

by Kathy Jones on April 17, 2014 at 8:53 PM
Font : A-A+

 Research Says Down's Chromosome Causes Genome-Wide Disruption

A new study has found that the extra copy of Chromosome 21 that causes Down's syndrome throws a spanner into the workings of all the other chromosomes as well.

Using data from a set of twins, one with Down's and one without, researchers found a major difference in how genes functioned between the two.

Advertisement

The twins were born from a single egg that split, which means their DNA code started off identical.

But the individual with Down's had an extra copy of Chromosome 21 -- a difference enabling the scientists to see how this might affect the same genome.
Advertisement

The additional chromosome had a knock-on effect on all the 22 other chromosomes, the team reported in the journal Nature.

"We were very surprised by this finding," said Audrey Letourneau of the University of Geneva Medical School who co-authored the study.

"It seems that this small, extra chromosome has a major influence on the entirety of the genome."

Chromosomes are made up of bundles of DNA called genes, which hold the information for cell function.

Humans have 23 pairs of chromosomes-- or a total of 46 per cell.

People with Down's Syndrome, about one in every 750, have a third, extra Chromosome 21 -- the smallest of all the chromosomes with about one percent of the DNA in a cell.

Down's is the world's leading genetically-caused mental disease, and also carries a heightened risk of heart defects, leukaemia, immune-system malfunction and premature Alzheimer's disease.

The results may help researchers "find substances that could reverse this gene-expression dysregulation, i.e. drugs that revert the expression of genes... back to normal," co-author Stylianos Antonarakis told AFP.

Source: AFP
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Health Benefits of Sea Buckthorn
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Birth Defect - Genetic Metabolic Defects Fahrīs Syndrome 

Recommended Reading
Down Syndrome
Down Syndrome is a congenital disorder among children commonly born to older mothers. The condition ...
Genetic Testing of Diseases
Genetic testing helps to confirm a genetic condition in an individual and involves q complex ......
Tips to Live Longer
Though life is temporary and short, it is possible to maximize the span of our existence by living ....
Birth Defect - Genetic
Achondroplasia is a genetic disorder which is one of the leading causes of dwarfism ...
Fahrīs Syndrome
Fahr''s syndrome is a rare, neurological disorder first described by Karl Theodor Fahr, a German neu...
Metabolic Defects
Metabolism is the sum total of all chemical and physical changes that take place in any organism tha...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use