Research Paves the Way to Develop New Drugs to Treat Heart Problems in Diabetics

by Shirley Johanna on  May 26, 2017 at 7:19 PM Diabetes News
RSS Email Print This Page Comment bookmark
Font : A-A+

Diabetes-induced changes in heartbeat are regulated by β1-adrenoceptor, finds a new study published in Experimental Physiology. This discovery could lead to the development of more targeted drugs to improve treatment of heart problems in people with diabetes.
Research Paves the Way to Develop New Drugs to Treat Heart Problems in Diabetics
Research Paves the Way to Develop New Drugs to Treat Heart Problems in Diabetics

Patients with type 2 diabetes can have problems with the regulation of their heartbeat. The heartbeat is partly regulated by receptors called beta-adrenoceptors. There are two different forms, the β1 and β2, and each has a different function. The study found that the diabetes-induced changes in heartbeat are predominantly regulated by the β1-adrenoceptor, and not the β2-adrenoceptor.

Show Full Article


Beta-blockers block hormones like adrenaline and can used to decrease heart rate and blood pressure in the treatment of conditions such as angina or high blood pressure. Some beta-blockers are not effective in reducing the heartbeat of diabetics and can even worsen the blood glucose levels of patients. It is not known which beta-adrenoceptor type is responsible for these effects. This study suggests that beta-blockers targeting the β1-adrenoceptor would be more effective for diabetics.

The researchers implanted two devices into a rat model of diabetes. The first device measured blood pressure and heartbeat, and the second device injected drugs that reduce heartbeat by targeting the beta-adrenoceptors. This approach allowed the researchers to distinguish between the contributions of the two different beta-adrenoceptors (β1 and β2).

Regis Lamberts, the corresponding author, said, "This study provides novel insight into the pathological basis of heart rate dysregulation in type 2 diabetes. This could help us develop drugs to better address heart problems in people with diabetes."



Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions
Advertisement

Recommended Reading

More News on:

Drug Toxicity Diabetes - Self-Monitoring of Blood Glucose (SMBG) Diabetes and Exercise Heart Healthy Heart Glycemic Index Type 2 Diabetes Statins Mitral Valve Prolapse Aortic Valve Stenosis 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive