About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Research on Protein Housekeeping Mechanism

by Mohamed Fathima S on February 5, 2019 at 4:15 PM
Font : A-A+

Research on Protein Housekeeping Mechanism

Scientists elucidated on a biological process that aids in the production of healthy cells and removes faulty or damaged proteins, inhibiting their accumulation in cells, tissues, and organs. These findings about a housekeeping mechanism that is common in all living things may help understand the reasons for neurological disorders and other conditions.

An improved understanding of how flaws can occur in protein production could help explain other diseases, including some forms of anemia and growth retardation.

Advertisement


Scientists from the University of Edinburgh used the simple model organism yeast to look at how proteins are produced. During this process, genetic information encoded in the DNA is first copied into a related molecule called RNA and then used to produce proteins.

The team concentrated on a part of this mechanism that removes proteins that become stalled part way through their formation. This clears the way for further proteins to be produced.
Advertisement

Scientists studied a yeast protein known as Hel2, using UV light to identify where this protein touches molecules involved in protein production. These interactions help Hel2 identify flaws in protein formation.

When researchers removed the parts of Hel2 in direct contact, this prevented the destruction of faulty proteins, showing that these contacts are important for the mechanism.

Partly formed proteins can not only be dysfunctional but may be toxic, for example when they form protein clumps resembling those associated with Alzheimer's or Parkinson's. The study, published in Nature Communications, was supported by the European Molecular Biology Organisation and Wellcome.

Dr Marie-Luise Winz, of the University of Edinburgh's School of Biological Sciences, who led the study, said: "The process of removing stalled proteins during production is found throughout nature, so we know that it is of fundamental importance to life. Greater knowledge of how this occurs could potentially aid progress in the understanding of many diseases."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Ways to Manage Stress during COVID-19 Pandemic
Can Adjusting Fatty Acid Intake Improve Mood in Bipolar Disorder Patients?
Insulin Resistance Doubles the Risk of Major Depressive Disorder
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Magical Millets for Your Health Baby Food - Basics Diet and Nutrition Tips for Athletes Nutrition IQ 

Recommended Reading
Parkinsons Disease
Parkinson's disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Wolff-Parkinson-White Syndrome (WPW)
Wolff-Parkinson-White syndrome is caused due to an extra electrical pathway in the heart, which ......
Nutritional Management of Parkinsons disease
Parkinson's disease is a brain disorder which leads to many other related effects. Nutrition plays ....
Ten Reasons of Unexplained Weight Loss that need to be Taken Seriously
Unexplained weight loss is often a consequence of physiological, psychological disorders. Learn ......
Baby Food - Basics
The healthiest baby foods can be made at home. Products from big brands that claim to develop infant...
Diet and Nutrition Tips for Athletes
Athletes can be physically fit by consuming a well balanced nutritious diet, which keeps them mental...
Magical Millets for Your Health
Millets are far more nutrient dense than wheat and rice. They are inexpensive and tasty too. Nutriti...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use