Researchers have always wondered how nicotine fosters addiction in individuals.
Unexpectedly, the researchers discovered that nicotine's ability to up-regulate* nAChRs relied on the retrograde transport of ∝6* nAChRs back from the Golgi to the ER by COPI-coated vesicles. The authors believe that Golgi-ER cycling (involving COPI vesicles) may be a common mechanism for up-regulation of other nAChRs by nicotine. Manipulation of this process could therefore help form new strategies for smoking cessation and neuroprotection against Parkinson's disease.
Smoking among Women
Tobacco use in women is on the rise. The health risks of tobacco are far too many has never done a woman any good psychologically or health-wise.
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Source: Eurekalert
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