Recent research has linked broccoli consumption to reduced prostate cancer risk.
Researchers have found that sulforaphane, a chemical found in broccoli, interacts with cells lacking a gene called PTEN to reduce the chances of prostate cancer developing.
Richard Mithen, from the Institute of Food Research, an institute of BBSRC, worked with a team of researchers on Norwich Research Park, UK, to carry out a series of experiments in human prostate tissue and mouse models of prostate cancer to investigate the interactions between expression of the PTEN gene and the anti-cancer activity of sulforaphane.
The research team found that in cells, which express PTEN, dietary intervention with SF has no effect on the development of cancer.
In cells that don't express the gene, however, sulforaphane causes them to become less competitive, providing an explanation of how consuming broccoli can reduce the risk of prostate cancer incidence and progression.
"This also suggests potential therapeutic applications of sulforaphane and related compounds," Mithen added.
The study appears in BioMed Central's open access journal Molecular Cancer.