About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Research Indicates How TB Bacteria Remains Latent and Fights Immunity for Decades

by Tanya Thomas on July 13, 2009 at 10:06 AM
Font : A-A+

 Research Indicates How TB Bacteria Remains Latent and Fights Immunity for Decades

Scientists from Memorial Sloan-Kettering Cancer Centre have identified a protein that helps TB bacteria resist immune response. This enables the bacteria to remain latent in the body for decades.

They hope that the new discovery may lead to new drugs to eliminate those strains of mycobacterium tuberculosis that have grown resistant to therapies currently available.

Advertisement

"Tuberculosis can resist the host immune system and remain latent for decades," said Michael Glickman, of the Memorial Sloan-Kettering Cancer Centre.

"To do so, the mycobacterium responsible must resist an arsenal of DNA-damaging mutagens produced within the macrophage, the immune cell in which it lives.
Advertisement

"It's incompletely understood how it can do that. We've identified one such mechanism," he added.

According to the researchers, secret to TB's success is a protein called CarD.

"The mycobacterium tailors its translational machinery in response to stress within the host and we have identified CarD as a critical mediator of this response" said Glickman.

The study showed that loss of CarD is fatal to M. tuberculosis living in cell culture.

CarD depletion leaves the pathogen sensitive to killing by oxidative stress, starvation, and DNA damage as it fails to cut its transcription of rRNA.

Glickman said that they were able to show in infected mice that the mycobacterium depends on CarD not just when it is in its early, most active phase of growth, but also later in the course of infection.

He added that drugs that target CarD's interaction with RNA polymerase could, therefore, lead to sorely needed, new TB drugs.

The study has been published in the journal Cell, a Cell Press publication.

Source: ANI
TAN
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Tuberculosis AIDS/HIV Shigellosis Immunisation MRSA - The Super Bug Myasthenia Gravis Blood Group Diet Silicosis Screening Tests for Tuberculosis Food Safety for Health 

Most Popular on Medindia

Sinopril (2mg) (Lacidipine) Color Blindness Calculator Vent Forte (Theophylline) Pregnancy Confirmation Calculator Find a Hospital Accident and Trauma Care Iron Intake Calculator Loram (2 mg) (Lorazepam) Post-Nasal Drip Daily Calorie Requirements
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Research Indicates How TB Bacteria Remains Latent and Fights Immunity for Decades Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests