About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Research Has Identified Ways to Make Cancer Cells More Responsive to Chemotherapy

by Rukmani Krishna on May 31, 2013 at 10:37 PM
Font : A-A+

 Research Has Identified Ways to Make Cancer Cells More Responsive to Chemotherapy

A new research has shed light on why some cancer cells don't respond to chemotherapy, and identified a mechanism to rectify that. The research is from Western University.

Breast cancer characterized as "triple negative" carries a poor prognosis, with limited treatment options. In some cases, chemotherapy doesn't kill the cancer cells the way it's supposed to.

Advertisement

Dr. Shawn Li, PhD, and his team at Western's Schulich School of Medicine and Dentistry, identified that a protein called Numb functions to promote the death of cancer cells by binding to and stabilizing a tumor suppressor protein called p53 -a master regulator of cell death.

The scientists found when Numb is reduced or methylated by an enzyme called Set8, it will no longer protect p53.

"If you don't have Numb in a cell, then the p53 can be degraded very quickly, and these cells become resistant to chemotherapy," explained Li, a professor of Biochemistry and Canada Research Chair in Cellular Proteomics and Functional Genomics.
Advertisement

"So if we can prevent Numb from being methylated in cancer cells, then we will have the means to sensitize the cell to chemotherapy," he explained.

Now that he's identified the Set8-Numb-p53 pathway, Li is investigating various drugs to find a Set8 inhibitor, which could be used as a novel breast cancer therapy alone, or in combination with other chemotherapy regiments.

The research has been published in the latest issue of Molecular Cell.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Parkinsons Disease Surgical Treatment Colorectal Cancer Chronic Lymphocytic Leukemia Hodgkins Lymphoma Non-Hodgkins Lymphoma Chemotherapy Chemotherapy Drugs Cancer Facts Cancer 

Recommended Reading
Chemotherapy
'Chemo' means medicine or 'drug'; 'therapy' means 'treatment'. Chemotherapy refers to the use of .....
Chemotherapy Drugs
Chemotherapy drugs perform like 'magic bullets' to destroy cancer cells in the body....
Toxoplasmosis
Brief overview of a common disease called Toxoplasmosis and its risks in human population...
Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia (CLL) is one of the most common types of adult leukemia and is consider...
Colorectal Cancer
Colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer is the third...
Hodgkins Lymphoma
Hodgkins lymphoma or Hodgkins disease has the distinction of being the first cancer to be cured by c...
Non-Hodgkins Lymphoma
Non Hodgkins Lymphoma is a cancer that affects the lymph tissues. It is made up of a wide array of ....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use