Delivering flu vaccines straight into the lungs rather than through routine jabs could trigger a stronger immune response, according to a new study by researchers at the University of Melbourne.
Since the world is expected to be extremely short of vaccines in the event of flu pandemic, an effective way to deliver them is significant because it would economise on the quantity of each dose.
Bird Flu
Bird flu (avian influenza/avian flu) is a disease caused by an influenza virus (H5N1) that primarily affects birds but can infect humans also.
Advertisement
In the study, researchers found that lower doses of a seasonal flu vaccine delivered into the lungs of sheep gave better protection against flu than a higher standard dose that was injected into another group of sheep.
"Our results suggest that delivery by the lung may allow a much lower ... dose to be used in the influenza vaccine, while inducing equivalent or perhaps even improved protection. This would mean more people would quickly be able to receive the vaccine," the Mirror quoted associate professor Philip Sutton of the Centre for Animal Biotechnology at the University of Melbourne, as stating.
![Biopsy-Introduction]( "Biopsy-Introduction")
For the study, researchers delivered three different doses of flu vaccines (15, 5 and 1 micrograms) into the lungs of three groups of sheep using a bronchoscope, or tube. A fourth group of sheep was injected with standard 15-microgram flu vaccines.
"Lung delivery produced superior levels of antibodies in the lung (approximately 1,000 times more), where the influenza virus infects, than the injected vaccine. The antibodies produced in the blood and lung were able to block the ability of the virus to stick to the receptor it uses to infect cells, demonstrating they would be effective against infection," Sutton said.
Sutton added: "The generation of functional antibodies in the lung could potentially help reduce the spread of the infection by neutralising the virus before it can be breathed out by an infected person."
However, he noted that better ways to deliver vaccine directly into the lungs are required.
The study is published in Mucosal Immunology.
Source: ANI
RAS/SK
Advertisement
For the study, researchers delivered three different doses of flu vaccines (15, 5 and 1 micrograms) into the lungs of three groups of sheep using a bronchoscope, or tube. A fourth group of sheep was injected with standard 15-microgram flu vaccines.
"Lung delivery produced superior levels of antibodies in the lung (approximately 1,000 times more), where the influenza virus infects, than the injected vaccine. The antibodies produced in the blood and lung were able to block the ability of the virus to stick to the receptor it uses to infect cells, demonstrating they would be effective against infection," Sutton said.
Sutton added: "The generation of functional antibodies in the lung could potentially help reduce the spread of the infection by neutralising the virus before it can be breathed out by an infected person."
However, he noted that better ways to deliver vaccine directly into the lungs are required.
The study is published in Mucosal Immunology.
Source: ANI
RAS/SK
Waterborne Disease - Animation
Interactive section of Medindia gives details regarding waterborne disease
Advertisement
Advertisement
|
Advertisement
Recommended Readings
Latest Research News
New study sheds light on the intrinsic, yet often overlooked, role of sleep preparation as a hardwired survival strategy.
Microgravity-induced bone loss in space, can be reduced by systemic delivery of NELL-1, a protein required for bone growth and its maintenance.
Researchers establish connections between Alzheimer's-linked genetic alterations and the functioning of brain cells.
Team at NeuroRestore introduces a groundbreaking gene therapy that has effectively promoted nerve regrowth and reconnection, post spinal cord injury.
Scientists aim to pinpoint particular functional pathways affected by these bacteria that may have an impact on skeletal health.
