Repurposed Drug Combats Fatal Super bug: Study

Vancomycin-resistant enterococcus (VRE), the fatal superbug that typically develop from infections in the intestinal tract, can be killed by a drug used for glaucoma and congestive heart failure, according to a study published in the Journal of Medicinal Chemistry.

Purdue University researchers from the College of Pharmacy and the College of Veterinary Medicine developed small molecules to combat deadly, drug-resistant enterococcus by repurposing a drug that has been used for more than 80 years to treat glaucoma, congestive heart failure and some other health issues.

‘New study results help to change the way people treat VRE in the future. Existing medication could combat deadly VRE.’
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"The potency of these molecules and the ability to tune the molecules' properties to target VRE in different compartments of the body make this an exciting project," said Daniel Flaherty, an assistant professor of medicinal chemistry and molecular pharmacology. "I believe our discovery may help to change the way people treat VRE in the future.

"We can have molecules that can be used to treat deadly systemic VRE infections, or through manipulation of the properties of the molecule, design a compound that will reside solely in the gastrointestinal tract to reduce VRE colonization. By working across disciplines at Purdue, we have been able to improve the effectiveness of this drug 600 times better than where we started in treating VRE."

Mohamed Seleem, a professor of microbiology, who co-created the molecules with Flaherty, said the problem with antibiotics on the market is that they are used for a wide variety of illnesses.

Vancomycin-Resistant Enterococci (VRE): Causes Symptoms Diagnosis Treatment
Enterococci are a group of gram-negative bacteria that mostly inhabit the human gut. At present there are very few antibiotics that are capable of treating enterococcal infections but research is being done on developing many more.

"These antibiotics can really rip apart the guts and destroy good bacteria," Seleem said. "Then someone can develop Clostridium difficile, also known as C. diff, which kills about 30,000 people each year in the United States. Scientists across the globe are working on better solutions, but I think we are far away from seeing narrow-spectrum antibiotics proliferate the market."

The Purdue team's small molecules have been shown to target VRE and have the properties necessary to treat VRE in both systemic circulation or in the GI tract, where all VRE infections originate.

Source-Eurekalert