About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Reproductive Capabilities of Females Affected by Environmental Pollutant BPA

by Kathy Jones on March 24, 2012 at 6:24 PM
Font : A-A+

 Reproductive Capabilities of Females Affected by Environmental Pollutant BPA

Bisphenol A (BPA) may affect a mammal's ability to reproduce by altering the structure of the uterus, which can actually progress to a potentially fatal infection.

This is the finding of a new study by researchers at the University of Cincinnati.

Advertisement

Infection and inflammation of the uterus, or pyometra, is most commonly seen in animals like dogs and cats but can also affect humans. It is a result of hormonal and structural changes in the uterus lining and can be deadly if left untreated.

"This condition can be caused by chronic exposure to estrogens; however, it is unknown whether estrogenic endocrine disruptors, like bisphenol A, can cause pyometra," said Scott Belcher, PhD, professor in the department of pharmacology and cell biophysics and principal investigator on the study.
Advertisement

"We wanted to see if dietary exposures to BPA induced the condition in animal models of differing sensitivity to estrogens," he revealed.

Belcher's team exposed the models to different dietary doses of BPA in their food, ranging from four to more than 4,000 micrograms per kilogram of body weight per day, or 17a-ethinyl estradiol (EE), a semi-synthetic steroidal estrogen, in doses of one to greater than 150 micrograms per kilogram of body weight per day. A control group received no dose of BPA or EE.

"Using two different strains of mouse models, we monitored to see which doses of endocrine disruptors affected which strains," Belcher explained.

"In a commonly used strain of mice, C57BL/6, pyometra occurred with 15 micrograms per kilogram of body weight per day of EE and 33 micrograms per kilogram of body weight per day of the BPA treatment groups," he said.

He also indicated that at the effective concentration of BPA, immune cell numbers in the uteri of the C57BL/6 strain animals exposed were increased five-fold compared with control animals. In a different strain of mouse (CD1), a similar increase in immune cell numbers required 100 times greater exposure.

"These results suggest that BPA enhances the immune responsiveness of the uterus and that the heightened responsiveness in the C57BL/6 strain of females is related to increased susceptibility to pyometra," he said.

Belcher added that the reason for this study was to compare appropriate concentrations of dietary estrogenic chemicals to allow reproduction-not to determine whether or not BPA had specific effects on reproduction or fertility.

"However, in the case where food consumption is altered and reproduction was completely blocked, some interesting and valuable insight to the impact of these dietary estrogens is possible," he said.

"It seems likely that the immunologic and structural differences between the strains indicate a potential key difference in susceptibility to developing pyometra, which is related to the immune response. We are extremely interested in understanding why some strains or individuals are insensitive to the effects of endocrine disruptors, while others are resistant to the harmful actions of these chemicals.

"The results here suggest that pyometra in the C57BL/6 strain might serve as a sensitive endpoint for understanding the mechanisms responsible for the impact of estrogen and estrogenic endocrine-disrupting chemicals on reproduction and also immunity. Further studies using the C57BL/6 strain might serve as a useful model of sensitive subpopulations at risk for developing immunological disorders related to exposures to estrogen disruptors like BPA," Belcher added.

These findings were published in March 9, 2012, advance online edition of the Journal of Reproductive Toxicology.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
Long-Term Glycemic Control - A Better Measure of COVID-19 Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.


Recommended Reading
Infertility
Infertility is a condition wherein couples fail to achieve pregnancy or if the woman has been ......
Genetics of Male Infertility
Encyclopedia section of medindia briefs you about the Genetics of Male Infertility...
In Vitro Fertilization (IVF)
Encyclopedia section of medindia gives a brief introduction to infertility and reproduction...
Genetic Counseling
Encyclopedia section of medindia gives general info about Genetic counseling ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use