J. Meyle, Justus Liebig University, Giessen, Germany, will present an abstract titled "P. gingivalis Infection and Immune Evasion of Oral Carcinomas" at the 88th General Session & Exhibition of the International Association for Dental Research, in Barcelona, Spain
Meyle and his team are investigating the relationship of oral cancers and periodontal disease. They achieved results by infecting cell carcinoma cells SCC-25 with Porphyromonas gingivalis (P.g.) W83. After 48h the cells were stained with antibodies against human B7-H1, B7-DC and TLR4 and analysed by flow cytometry. RNA was extracted after 24h and gene expression of B7-H1, B7DC, TLR4, IFN-γ and IL-10 was quantified by real time PCR and analysed by the ΔΔCT method.
Women and Cancer
Cancer is one of the frequently talked about and most feared disease that falls under the genre of lifestyle diseases that have evolved, rather rapidly, in the past two decades.
Advertisement
Up-regulation of B7-H1 in host cells may contribute to the chronicity of inflammatory disorders which frequently precede the development of human cancers. B7-H1 expression was detected in the majority of human cancers and leads to anergy and apoptosis of activated T cells, which might enable tumors to evade the immune response. TLR4 signalling has been shown to induce B7-H1 in bladder cancer cells.
P.g., a putative periodontal pathogen, is an etiologic agent of periodontitis and expresses a variety of virulence factors. In this study the expression of B7-H1 and B7-DC receptors and TLR4 on squamous cell carcinoma cells SCC-25 was analysed after infection with P.g. in vitro.
The research concludes that P.g. is able to induce the expression of the immune regulating receptors B7-H1 and B7-DC in squamous cell carcinoma which may facilitate immune evasion of oral cancers in patients with periodontal infections.
Source: Eurekalert
The research concludes that P.g. is able to induce the expression of the immune regulating receptors B7-H1 and B7-DC in squamous cell carcinoma which may facilitate immune evasion of oral cancers in patients with periodontal infections.
Source: Eurekalert
Tongue Abnormalities
Tongue is the only muscle that is attached to only one end. The abnormalities of the tongue include tongue disease, tongue tie and size-related anomalies.
Advertisement
Advertisement
|
Advertisement
Recommended Reading
Latest Dental News
New study highlights the development of an innovative adhesive patch capable of treating two common oral health disorders.
Dental anxiety is the fear, anxiety, or stress associated with things like needles, drills, or the dental setting in general that may delay or avoid dental treatment.
Does missing teeth replacement strength memory loss? Yes, the replacement of missing teeth with fixed prostheses may protect against cognitive decline.
Diabetes mellitus (DM) is a recognized risk factor for dementia, and increasing evidence shows that tooth loss is also associated with cognitive impairment and dementia.
Soft gums tend to show high susceptibility to the disruption of gum health because of mechanotransduction-mediated proinflammatory responses in gingival fibroblasts.