About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

'Regulatory' Genetic Sequences That Predicts Prostate Cancer Risk Identified

by VR Sreeraman on August 17, 2009 at 4:51 PM
Font : A-A+

 'Regulatory' Genetic Sequences That Predicts Prostate Cancer Risk Identified

Researchers at the Keck School of Medicine of the University of Southern California (USC) have identified a novel genetic mechanism that may govern an individual's risk of developing prostate cancer.

The findings, published today in the Public Library of Science (PLoS) Genetics journal, found mechanisms involved in cancer-associated sites in areas where no genes are present (gene 'deserts') at a chromosomal region called 8q24. The new findings show that some of these sites have embedded regulatory sequences that act as enhancers of gene expression, modulated by genetic variation, or single nucleotide polymorphisms (SNPs).

Advertisement

The two-year study, conducted by researchers from USC, Harvard University and the Weizmann Institute of Tel Aviv, Israel, found novel functions of SNPs in areas where no genes were present. They found how the SNPs are able to modulate genetic expression even while they were near no genes. SNPs denote a modest increase in risk for certain diseases; in this particular chromosomal area, the SNPs appear to be influencing gene expression for prostate (and other) cancer 'at a genetic distance'.

"The real contribution of this discovery is that we get a feel for a previously unappreciated mechanism that may be a predisposition to this disease," said Gerhard (Gerry) Coetzee, Ph.D., professor of urology and preventive medicine at the Keck School of Medicine and principal investigator on the study. "We have unearthed a new way to understand the risk for prostate cancer."
Advertisement

The study was prompted by discrepancies in prostate cancer risk among ethnic groups. Currently, risk factors for prostate cancer are governed by age, and a disproportionate increased risk chiefly among African-American men, with Caucasian men following and Asian men last. This gene 'desert' featuring versions of particular SNPs are found more often in African-American men and may explain their increased risk for the disease.

Source: Eurekalert
LIN
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge About Chromosomes?
Eating During Sunlight Hours Minimizes Mood Vulnerabilities
Know More About the Digestive System
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Prostate Cancer Cancer and Homeopathy Trans-Urethral Resection of the Prostate Genetics and Stem Cells Prostate Cancer Facts Cancer Facts Cancer Tattoos A Body Art Prostate Cancer: Treatment Options Prostate Specific Antigen [PSA] 

Most Popular on Medindia

Drug Interaction Checker Blood Donation - Recipients Blood Pressure Calculator Calculate Ideal Weight for Infants Drug Side Effects Calculator Turmeric Powder - Health Benefits, Uses & Side Effects How to Reduce School Bag Weight - Simple Tips Noscaphene (Noscapine) Iron Intake Calculator Selfie Addiction Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

'Regulatory' Genetic Sequences That Predicts Prostate Cancer Risk Identified Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests