About Careers MedBlog Contact us

Regulatory Defect That Drives Lupus Identified

by Kathy Jones on February 6, 2011 at 2:11 PM
Font : A-A+

 Regulatory Defect That Drives Lupus Identified

A regulatory defect that drives lupus has been identified by a group of scientists.

Correcting the defect 'may represent an effective therapeutic approach to systemic lupus erythematosus-like autoimmune disease,' according to researchers at Dana-Farber Cancer Institute in Cambridge, Mass., and Jackson Laboratory scientists.


The research team was led by Harvey Cantor, chair of the department of cancer immunology and AIDS at Dana-Farber, in collaboration with the laboratory of Jackson Professor Derry Roopenian.

Autoimmune diseases develop when the immune system, which is supposed to identify and vanquish potentially dangerous infectious agents, instead attacks the individual's own body.

Most autoimmune diseases strike specific organs, such as the pancreas in type1 diabetes. Lupus, however, is a systemic disease in which abnormal antibodies are produced throughout the body, inflaming a variety of tissues and organs, including the skin, heart, lungs, kidneys and brain.

Follicular T helper (TFH) cells fuel B cells to produce antibodies, which can be useful in fighting infections. But in lupus, TFH fuel B cells that produce dangerous antibodies that attack normal tissues (autoantibodies).

CD8+ T cells ("killer T cells"), on the other hand, normally attack and destroy only infected cells.

Cantor and colleagues discovered that a small, but critically important, population of CD8+ T cells (less than 5 percent), plays a specialized role in protecting from lupus.

These so-called CD8+ T regulatory, or Treg, cells are specially equipped to destoy TFH cells, and by doing so, prevent lupus from developing.

Using a mouse model for systemic lupus erythematosus in humans, the research team found defects in CD8+ Treg activity.

he research was published in the Proceedings of the National Academy of Sciences.

Source: ANI

Recommended Reading

This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Regulatory Defect That Drives Lupus Identified Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests