About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Reducing Cell Turnover in Intestinal Lining may Treat Irritable Bowel Syndrome

by Shirley Johanna on April 6, 2016 at 11:25 AM
Font : A-A+

Reducing Cell Turnover in Intestinal Lining may Treat Irritable Bowel Syndrome

The most rapidly-renewing tissue in the body is the lining of the intestine. Routine shedding of epithelial cells from intestinal lining is the key element of tissue turnover, which is essential to maintain optimal health.

Altered shedding is associated with multiple disorders, ranging from inflammatory bowel disease (IBD) to colorectal cancer.

Advertisement


Researchers at The Saban Research Institute of Children's Hospital Los Angeles (CHLA) looked at ways such shedding and cell regeneration are controlled in healthy intestine.

Their study, currently published online in the Journal of Cell Science, showed that shedding is negatively regulated by epidermal growth factor (EGF) - an important driver of intestinal growth and differentiation.
Advertisement

"We found that, surprisingly, EGF suppresses shedding of epithelial cells in the intestine through a selective, MAPK-dependent signaling pathway," said CHLA researcher Mark R. Frey, who is also an assistant professor of Pediatrics and Biochemistry at the Keck School of Medicine of the University of Southern California. His team used coordinated in vitro models (cell culture and 3-D culture systems) to study the effects of blocking MAPK pathways. Similar results were found in vivo, in a novel zebrafish model for intestinal epithelial shedding.

This insight could identify potential targets for correcting pathological shedding in diseases such as IBD.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Constipation Parkinsons Disease Surgical Treatment Crohns Disease Irritable Bowel Syndrome Pelvic Pain in Women Constipation-Symptom Evaluation Abdominal Distension Health Benefits of Probiotic Yogurt Diet 

Most Popular on Medindia

Find a Doctor Nutam (400mg) (Piracetam) Sinopril (2mg) (Lacidipine) A-Z Drug Brands in India Blood - Sugar Chart Daily Calorie Requirements Accident and Trauma Care Blood Donation - Recipients Drug Side Effects Calculator The Essence of Yoga
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Reducing Cell Turnover in Intestinal Lining may Treat Irritable Bowel Syndrome Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests