Medindia
Advertisement

Recurrent Urinary Tract Infections Linked to Immune System Overreaction

by Kathy Jones on August 15, 2010 at 12:16 PM
Font : A-A+

 Recurrent Urinary Tract Infections Linked to Immune System Overreaction

The immune system may open the door to recurrent urinary tract infections (UTIs) by overdoing its response to an initial infection, researchers at Washington University School of Medicine in St. Louis have found.

The research was conducted at the Center for Women's Infectious Disease Research at the School of Medicine.

Advertisement

UTIs affect millions of people each year. Although antibiotics are the primary treatment, antibiotic resistance is a growing concern, according to Scott Hultgren, PhD, the center's director. Symptoms include frequent, painful urination, blood or cloudiness in the urine and fatigue.

"Women and infants are at greatest risk for UTIs, and chronic and recurrent infections are common," says Hultgren, the Helen L. Stoever Professor of Molecular Microbiology.
Advertisement

"The diagnosis and treatment of UTIs in the United States is estimated to cost $1.6 billion annually.

In the study, researchers infected mice with UTIs for a month. Some mice spontaneously resolved their infections; others developed a persistent infection that Hultgren's group calls chronic bacterial cystitis. These mice persistently had high levels of bacteria in their urine and bladder and high levels of inflammation in the urinary tract.

"Chronic bacterial cystitis is an infection that is actively reproducing, has established a persistent and significant foothold in the host's bladder and has prompted a sustained response from the immune system," says Hannan, a research instructor in pathology and immunology.

"Despite all this, the infection is still well-tolerated by the mice."

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Gonorrhea
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cystitis Cystoscopy Urinary Tract Infection Immunisation Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Diet for Kidney stones Stones in Urinary Tract Interstitial Cystitis Myasthenia Gravis 

Recommended Reading
Urinary Stone Disease
Stones in the urinary system can form in the kidneys and can sometimes travel down towards the ......
Stones in Urinary Tract
Ask people who have suffered from urinary stones and they will tell you how excruciating the pain .....
Vesico-Ureteric Reflux Causing UTI in Children
Bacterial infection of urinary bladder can cause pain and burning sensation while passing urine. ......
Cystitis
Cystitis is an inflammation of the urinary bladder. Cysitis is caused by bacteria and women are more...
Cystoscopy
Cystoscopy is a procedure wherein the urologist visualizes the lining of the urinary bladder and the...
Diet for Kidney stones
Diet for kidney stone should comprise of calcium-rich foods, increased fluid intake. Other dietary r...
Hydronephrosis / Antenatal Counseling
Currently most pregnant women undergo one or two ultrasound scans during their pregnancy....
Interstitial Cystitis
Interstitial cystistis is an umbrella term where a pathology cannot be defined but the patient suf...
Myasthenia Gravis
Myasthenia gravis is the commonest disorder of neuromuscular transmission. Autoimmune myasthenia gra...
Urinary Tract Infection
Urinary tract infection (UTI) is a bacterial infection which can happen anywhere along the urinary ....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use