About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Receptor Vital for Development of Insulin Producing Cells Identified

by Kathy Jones on July 19, 2012 at 6:22 PM
Font : A-A+

 Receptor Vital for Development of Insulin Producing Cells Identified

A joint study conducted by researchers at Western University, Canada and Children's Health Research Institute has identified a receptor, known as c-Kit, which plays an important role in the development and function of insulin producing beta cells.

The research, led by Rennian Wang, demonstrated that overexpression of c-Kit not only leads to increased insulin production but also counteracts the early diabetic effects of a high-fat diet. The paper and an accompanying commentary, are published in the August issue of Diabetologia, and featured in the Research Highlights in Nature Reviews Endocrinology (June 5).

Advertisement

Diabetes is one of the most common metabolic diseases affecting over 25 million Americans and 2 million Canadians. It's associated with a multitude of complications leading to considerable morbidity and a major medical as well as financial burden on society.

One of the major defects in diabetes is the loss of beta cells in the pancreatic islet. Wang and colleagues, including Zhi Chao Feng, a PhD candidate and first author on the paper, developed a transgenic mouse model (c-Kit Wv) which overexpressed c-Kit, specifically in beta cells. "When c-Kit is overexpressed, we observed a significant improvement in beta cell function and survival," says Wang, a Professor in the Departments of Physiology and Pharmacology, and Medicine at Western's Schulich School of Medicine & Dentistry. "You can even rescue c-Kit mutant mice from the early onset of diabetes, and protect against high-fat diet-induced beta cell defects. This is a novel finding and is being reported for the first time."
Advertisement

Wang believes ongoing research into c-Kit and its underlying mechanisms, will pave the way to develop strategies to preserve and restore function to beta cells as a cure for both type 1 and type 2 diabetes. This study was funded by the Canadian Institutes of Health Research.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Are Menopause Symptoms Troubling You?: Try these Options
Vaccination  And Counter  Measures Against  Monkeypox
Indian Railways Special Concession on Health Grounds
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diabetes - Essentials Parkinsons Disease Surgical Treatment Gestational diabetes Type 2 Diabetes Diabetes - Foot Care Diabesity Diabetes in Pets Diabetes Facts and Figures Insulin Hormone Hypoglycemia (Low Blood Sugar) 

Most Popular on Medindia

Pregnancy Confirmation Calculator How to Reduce School Bag Weight - Simple Tips Indian Medical Journals Find a Doctor Noscaphene (Noscapine) A-Z Drug Brands in India Vent Forte (Theophylline) Iron Intake Calculator Post-Nasal Drip Daily Calorie Requirements

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use