An effort to fine-tune descriptions, or phenotypes, of Multiple sclerosis was taken by an international team of leaders in MS research and clinical care. The results of this effort by the International Advisory Committee on Clinical Trials in MS, including recommendations for more research, has just been published (Neurology 2014;83:1). The volunteer Committee is jointly supported by the National MS Society and the European Committee for Treatment and Research in MS (ECTRIMS).
"Having better definitions of different types of MS would greatly facilitate research studies, communications between people with MS and their healthcare providers, and treatment decisions," noted Timothy Coetzee, PhD, Chief Advocacy, Services and Research Officer of the National MS Society.
Multiple Sclerosis
Multiple sclerosis can be a severely disabling autoimmune disease that affects the myelin or insulating layer of the nerve fibers and typically has remissions and relapses
Advertisement
In 1996 the Committee had developed consensus around descriptions of the courses of MS to facilitate research in MS and so that researchers and clinicians around the world would have a common understanding of the types of MS discussed in publications and in the clinic. This consensus highlighted four courses of MS -- relapsing-remitting, secondary progressive, primary progressive, and progressive relapsing. While these descriptions of MS have become well-established, understanding of MS has advanced, prompting a re-evaluation of the course of MS and any biological signposts (such as blood markers or imaging) that might help refine these phenotypes.
After a thorough search of the medical literature and convening an international workshop funded by collaborators worldwide (National MS Society, ECTRIMS, Americas Committee for Treatment and Research in MS, MS International Federation, and MS Society of Canada), the Committee published recommendations that modify prior clinical course descriptions. The Committee recommended retaining major courses of MS - relapsing-remitting, secondary-progressive and primary progressive -- but recommended categorizing progressive relapsing as an active form of primary progressive MS.
![World Multiple Sclerosis Day 2014]( "World Multiple Sclerosis Day 2014")
World Multiple Sclerosis Day 2014 with its theme 'Access' aims at raising global awareness on Multiple Sclerosis, the disease affecting young adults, and improving the quality of life of MS sufferers.
Importantly, they recommended that clinicians not just determine a person's course of MS, but further sub-categorize that course as "active" or "not active" (depending on the presence of clinical relapses or activity on MRI scans) or as progressing (worsening) or not progressing, based on clinical evidence of changes in disability. "This will provide a truer picture of what an individual experiences," added Dr. Coetzee.
"These revisions should make communication with patients and among physicians clearer and should also enhance the design, recruitment and conduct of clinical trials, which will further help us understand the disease," noted Fred D. Lublin, MD, Director of the Corinne Goldsmith Dickinson Center for Multiple Sclerosis at The Icahn School of Medicine at Mount Sinai, and the article's lead author.
Areas recommended for further research by the Committee include long-term studies to track people with MS over time, imaging studies to gain a window on brain and spinal cord damage caused by the disease, biomarkers that might differentiate types of MS, and patient-reported outcomes. Researchers funded by the National MS Society and others worldwide are already working toward many of these goals, in efforts to help people with MS live their best lives. In addition, this information will be considered by the Society's leadership as it develops future research strategies.
Source: Eurekalert
World Multiple Sclerosis Day 2014
World Multiple Sclerosis Day 2014 with its theme 'Access' aims at raising global awareness on Multiple Sclerosis, the disease affecting young adults, and improving the quality of life of MS sufferers.
Advertisement
Importantly, they recommended that clinicians not just determine a person's course of MS, but further sub-categorize that course as "active" or "not active" (depending on the presence of clinical relapses or activity on MRI scans) or as progressing (worsening) or not progressing, based on clinical evidence of changes in disability. "This will provide a truer picture of what an individual experiences," added Dr. Coetzee.
"These revisions should make communication with patients and among physicians clearer and should also enhance the design, recruitment and conduct of clinical trials, which will further help us understand the disease," noted Fred D. Lublin, MD, Director of the Corinne Goldsmith Dickinson Center for Multiple Sclerosis at The Icahn School of Medicine at Mount Sinai, and the article's lead author.
Areas recommended for further research by the Committee include long-term studies to track people with MS over time, imaging studies to gain a window on brain and spinal cord damage caused by the disease, biomarkers that might differentiate types of MS, and patient-reported outcomes. Researchers funded by the National MS Society and others worldwide are already working toward many of these goals, in efforts to help people with MS live their best lives. In addition, this information will be considered by the Society's leadership as it develops future research strategies.
Source: Eurekalert
Nanoparticles can Arrest Multiple Sclerosis
Nanoparticles can be easily produced in laboratory and can be standardized for manufacturing and they can render the potential therapies quite cost friendly and easily accessible to general people.
Advertisement
 Scientists Develop a Better Tool for Tracking Multiple SclerosisAt Western University's Robarts Research Institute (London, Canada), imaging scientists have developed a better way to track the progression of Multiple Sclerosis (MS) from its earliest stages. | Advertisement
|
Advertisement
Recommended Readings
Latest General Health News
The Pakistan Ministry has announced the commencement of a nationwide polio vaccination campaign beginning on October 2, aiming to immunize more children.
In a tragic incident, a woman in the US experienced the loss of all her limbs as a result of a bacterial outbreak linked to the consumption of contaminated fish.
FluMos-v2, a unique universal influenza vaccine candidate, undergoing a phase 1 trial at NIH, increases recipients' immunity against many influenza viruses.
In Pakistan, the polio campaign focuses on more than 270,000 children under the age of five years, residing in areas with insufficient vaccine coverage.
Dangers of Wrong Diagnosis: Diagnostic errors in healthcare can increase the risk of permanent disabilities and deaths.
