About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Rarest Immune Cell Shows Potential to Fight Against Cancer

by Megha Ramaviswanathan on February 26, 2018 at 11:28 AM
Font : A-A+

Rarest Immune Cell Shows Potential to Fight Against Cancer

A rarest immune cell, ILC2 that was unknown to scientists a decade ago may help to stop cancer cells from spreading to other parts of the body, according to new research from the University of British Columbia.

Cancer immunotherapy -- harnessing a person's own immune system to destroy cancerous cells -- has taken off in the past few years, as clinical trials have shown that it can be effective for some patients with blood-borne cancers, such as lymphoma. But it can also have severe side effects, and has been less successful in treating solid tumors.

Advertisement


Wilf Jefferies, a Professor in Department of Medical Genetics and the Department of Microbiology and Immunology, discovered in 2016 that cancer cells lacking a protein called interleukin-33 (IL-33) become "invisible" to the immune system, allowing the cells to proliferate and then metastasize. That finding led him to train his sights on the cells that get activated by IL-33: Type-2 innate lymphoid (ILC2) cells.

ILC2 cells were discovered by scientists exploring the genesis of asthma, an autoimmune disease that causes inflammation of the airways. But ILC2 cells, like many immune cells, likely have both negative and positive effects.
Advertisement

Dr. Jefferies and his team at UBC's Michael Smith Laboratories implanted lung cancer cells in mice that were genetically engineered to lack ILC2 cells. Their initial focus was whether the cancer cell clusters, implanted in the rear legs, grew in size more rapidly in the genetically engineered mice than they did in a control group of mice with a normal complement of ILC2 cells.

The tumors did expand more quickly, but he and his collaborator, Fumio Takei, a professor in the UBC Department of Pathology and Laboratory Medicine, found the biggest difference between the genetically engineered mice and the controls was the spreading of cancer to other parts of the body.

Primary lung cancer cells, which usually stay put, became mobile in the genetically engineered mice, appearing the lungs, brain, adrenal gland and lymphoid tissue. Meanwhile, metastatic cells roamed virtually unchecked, appearing in the brains of ILC2-deficient mice in quantities 1,000 times greater than those in the controls.

From those and other results, published this month in Scientific Reports , Dr. Jefferies and his team have concluded that ILC2 cells play a crucial role in preventing or slowing metastasis in lung and prostate cancer by unleashing the killing power of T-cells, another type of immune cell that kills cancer cells on contact.

Dr. Jefferies is currently completing an alternate version of that experiment - studying whether infusing mice with ILC2 cells can arrest the spread of implanted cancers.

Dr. Jefferies, the head of immune-oncology at the Vancouver Prostate Centre, believes that these findings, if further validated in animal models with implanted human cells, could provide the basis for testing whether infusion of ILC2 cells into cancer patients slows their spread. He also sees potential in testing infusion of the protein IL-33, which is already synthesized by commercial labs, to see whether it can trigger a patient's own store of ILC2 cells.

What makes ILC2 cells particularly promising as a cell-based therapy is that they do not need to be activated by a specific cancer antigen - a "flag" that invites immune cells to attack. That means ILC2 cells wouldn't have to be manipulated in a lab prior to using them as a treatment, as is the case with the leading immunotherapies, such as CAR-T cells.

"These results raise the possibility that harnessing the immune system to fight cancer might be a matter of more effectively triggering ILC2 cells with IL-33, or simply having more ILC2 cells - or perhaps a combination of both," Dr. Jefferies said.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Goji Berries May Protect Against Age-Related Vision Loss
Tapping — A Proven Self-Applied Stress Intervention
Black Pepper as Preventive Measure Against Omicron
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Parkinsons Disease Surgical Treatment Cancer Facts Cancer Tattoos A Body Art Myasthenia Gravis Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant 

Recommended Reading
Cancer Immunotherapy
Cancer immunotherapy is a new advancement in cancer treatment that uses certain components of a ......
Prostate Cancer: Treatment Options
Treatment options of prostate cancer includes waiting, surgery, radiation, hormone therapy, ......
The Cause of Lung Cancer-Associated Dyspnea Identified
Lung cancer triggers pulmonary hypertension. Dyspnea is common among patients with advanced-stage .....
Lung Cancer Guideline Updated
Leading medical organizations update guideline for molecular testing and targeted therapies in lung ...
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Health Benefits of Dandelion Plant
What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health benefits. ...
Myasthenia Gravis
Myasthenia gravis is the commonest disorder of neuromuscular transmission. Autoimmune myasthenia gra...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)