When single strands of our DNA are damaged, a genetic mutation in a gene called XRCC1 causes a vital DNA-repairing enzyme (known as PARP1) in our bodies to over-activate.
British researchers have discovered a new genetic disease which results in neuro-degeneration and help find treatments for brain ageing conditions, such as Alzheimer's, Huntington's and Parkinson's.
Alzheimers Disease
Alzheimer''s disease is a progressive neurodegenerative disease affecting memory and thinking and making the person increasingly dependent on others.
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‘Ataxia oculomotor apraxia type XRCC1 is caused by a genetic mutation that disrupts the repair of our DNA.’
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The study revealed that the disease, ataxia oculomotor apraxia type XRCC1 is caused by a genetic mutation that disrupts the repair of our DNA. In people suffering from the new disease, the speeding up of this key enzyme actually triggers the death of brain cells, the researchers said.
"Discovering this new disease and its cause is a huge step towards developing drug-based therapies for other rare neurodegenerative conditions," said lead author Keith Caldecott, Professor at University of Sussex.
![Inability to Recognize Familiar Smells Could Signal Alzheimers]( "Inability to Recognize Familiar Smells Could Signal Alzheimers")
People who have difficulty recognizing familiar smells could be experiencing an early sign of Alzheimer's disease, according to a study published Monday.
Drugs which target this key DNA repairing enzyme in the right way, could prove vital for treating people suffering from diseases caused by the over-activation of this protein - it is now crucial we determine what diseases these are.
Single strand breaks are one of the most common types of DNA damage and the researchers believe it's possible the discovery of this new genetic disease could be important for scientists researching other rare DNA repair related diseases.
Source: Medindia
Inability to Recognize Familiar Smells Could Signal Alzheimers
People who have difficulty recognizing familiar smells could be experiencing an early sign of Alzheimer's disease, according to a study published Monday.
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Drugs which target this key DNA repairing enzyme in the right way, could prove vital for treating people suffering from diseases caused by the over-activation of this protein - it is now crucial we determine what diseases these are.
Single strand breaks are one of the most common types of DNA damage and the researchers believe it's possible the discovery of this new genetic disease could be important for scientists researching other rare DNA repair related diseases.
Source: Medindia
Risk Factors for Alzheimers Disease
Cognitively normal adults exhibiting atrophy of their temporal lobe or damage to blood vessels in the brain are more likely to develop Alzheimer's disease.
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 Brain Protein Could be Targeted to Slow Alzheimer’s, Study RevealsA protein that is involved in limiting flexibility in the aging brain could be targeted by new treatments which can slow the progression of Alzheimer's disease. | Advertisement
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